Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins - PubMed (original) (raw)
Review
Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins
Anna-Marija Helt et al. Carcinogenesis. 2003 Feb.
Abstract
Small DNA tumor viruses have evolved different mechanisms to abrogate the function of the retinoblastoma tumor suppressor (pRb). Studies of these viruses have been invaluable in uncovering the central role of the Rb family of pocket proteins in cell cycle control. While the molecular mechanisms by which the viral oncoproteins inactivate the Rb family are still being elucidated, it is clear that targeting of this family is required both for viral replication and for virus-induced transformation of mammalian cells. This review compares and contrasts the approaches DNA tumor viruses have evolved to antagonize Rb family members--ranging from relatively simple equilibrium dissociation of pRb from cellular pRb-binding factors to chaperone-mediated alterations in pocket protein stability and phosphorylation levels. The review will focus on the viral oncoproteins adenovirus E1A, human papillomavirus E7 and the large T antigens of several polyomaviruses. An understanding of these mechanisms may provide further insight into the regulation and functions of Rb family members as well as uncover new targets for the development of novel anti-viral agents, particularly against human papillomavirus, which is a significant cause of human cancer.
Similar articles
- Cellular proteins that are targetted by DNA tumor viruses for transformation.
Dyson N, Buchkovich K, Whyte P, Harlow E. Dyson N, et al. Princess Takamatsu Symp. 1989;20:191-8. Princess Takamatsu Symp. 1989. PMID: 2488232 Review. - Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery.
Bellacchio E, Paggi MG. Bellacchio E, et al. J Cell Physiol. 2013 Feb;228(2):285-91. doi: 10.1002/jcp.24137. J Cell Physiol. 2013. PMID: 22718244 Review. - Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor.
Lee C, Cho Y. Lee C, et al. Rev Med Virol. 2002 Mar-Apr;12(2):81-92. doi: 10.1002/rmv.340. Rev Med Virol. 2002. PMID: 11921304 Review. - Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins.
Felsani A, Mileo AM, Paggi MG. Felsani A, et al. Oncogene. 2006 Aug 28;25(38):5277-85. doi: 10.1038/sj.onc.1209621. Oncogene. 2006. PMID: 16936748 Review. - Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor.
Ledl A, Schmidt D, Müller S. Ledl A, et al. Oncogene. 2005 May 26;24(23):3810-8. doi: 10.1038/sj.onc.1208539. Oncogene. 2005. PMID: 15806172
Cited by
- Therapeutic Strategies in Advanced Cervical Cancer Detection, Prevention and Treatment.
Sebutsoe XM, Tsotetsi NJN, Jantjies ZE, Raphela-Choma PP, Choene MS, Motadi LR. Sebutsoe XM, et al. Onco Targets Ther. 2024 Sep 25;17:785-801. doi: 10.2147/OTT.S475132. eCollection 2024. Onco Targets Ther. 2024. PMID: 39345275 Free PMC article. Review. - Targeted inhibition of BET proteins in HPV16-positive head and neck squamous cell carcinoma reveals heterogeneous transcriptional responses.
Rao A, Stosic MS, Mohanty C, Suresh D, Wang AR, Lee DL, Nickel KP, Chandrashekar DS, Kimple RJ, Lambert PF, Kendziorski C, Rounge TB, Iyer G. Rao A, et al. Front Oncol. 2024 Sep 5;14:1440836. doi: 10.3389/fonc.2024.1440836. eCollection 2024. Front Oncol. 2024. PMID: 39301555 Free PMC article. - The effect of phosphorylation efficiency on the oncogenic properties of the protein E7 from high-risk HPV.
Malone M, Maeyama A, Ogden N, Perry KN, Kramer A, Bates C, Marble C, Orlando R, Rausch A, Smeraldi C, Lowey C, Fees B, Dyson HJ, Dorrell M, Kast-Woelbern H, Jansma AL. Malone M, et al. Virus Res. 2024 Oct;348:199446. doi: 10.1016/j.virusres.2024.199446. Epub 2024 Aug 14. Virus Res. 2024. PMID: 39127239 Free PMC article. - VEGF as a Key Actor in Recurrent Respiratory Papillomatosis: A Narrative Review.
Gazzini S, Cerullo R, Soloperto D. Gazzini S, et al. Curr Issues Mol Biol. 2024 Jul 1;46(7):6757-6768. doi: 10.3390/cimb46070403. Curr Issues Mol Biol. 2024. PMID: 39057045 Free PMC article. Review. - Molecular Mechanisms of Carcinogenesis in Pediatric Airways Tumors.
Soloperto D, Gazzini S, Cerullo R. Soloperto D, et al. Int J Mol Sci. 2023 Jan 22;24(3):2195. doi: 10.3390/ijms24032195. Int J Mol Sci. 2023. PMID: 36768522 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources