Semaphorin junction: making tracks toward neural connectivity - PubMed (original) (raw)

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Semaphorin junction: making tracks toward neural connectivity

R Jeroen Pasterkamp et al. Curr Opin Neurobiol. 2003 Feb.

Abstract

Semaphorins constitute one of the largest families of repulsive and attractive growth cone guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with receptor complexes composed of ligand-binding, signal-transducing, and modulatory subunits. Our understanding of the intracellular signal transduction machinery linking semaphorins to actin dynamics is limited; however, recent advances provide a more comprehensive view of the molecular basis of neuronal semaphorin signaling.

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