Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus - PubMed (original) (raw)

Comparative Study

Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus

Kara Pham et al. Eur J Neurosci. 2003 Feb.

Abstract

Chronic restraint stress has been shown to induce structural remodelling throughout the interconnected dentate gyrus-CA3 fields. To find out how this stressor affects the rate of adult hippocampal neurogenesis, we subjected rats to acute or chronic restraint stress and assessed the proliferation, survival and differentiation of newly born cells in the dentate gyrus. We also examined polysialylated neural cell adhesion molecule expression, a molecule normally expressed in immature neurons and important for morphological plasticity. The results show that acute restraint stress did not change either the proliferation of dentate gyrus precursor cells or the expression of polysialylated neural cell adhesion molecule, whereas 3 weeks of chronic restraint stress suppressed proliferation by 24% and increased polysialylated neural cell adhesion molecule expression by 40%. The study was extended for an additional 3 weeks to trace the survival and development of the cells born after the initial 3 weeks of restraint. Rats subjected to 6 weeks of daily restraint stress exhibited suppressed cell proliferation and attenuated survival of the recently born cells after the extended time course, resulting in a 47% reduction of granule cell neurogenesis. Furthermore, 6 weeks of chronic stress significantly reduced the total number of granule cells by 13% and the granule cell layer volume by 5%. Expression of polysialylated neural cell adhesion molecule followed a biphasic time course, displaying a significant up-regulation after 3 weeks of daily restraint stress that was lost after 6 weeks of stress. These studies may help us understand the basis for hippocampal shrinkage and raise questions about the ultimate reversibility of the effects of chronic stress.

PubMed Disclaimer

Cited by

[Neurogenesis. Relevance for pathophysiology and pharmacotherapy of psychiatric diseases].
Thome J, Eisch AJ. Thome J, et al. Nervenarzt. 2005 Jan;76(1):11-9. doi: 10.1007/s00115-004-1775-7. Nervenarzt. 2005. PMID: 15316619 Review. German.
Stress-induced structural remodeling in hippocampus: prevention by lithium treatment.
Wood GE, Young LT, Reagan LP, Chen B, McEwen BS. Wood GE, et al. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3973-8. doi: 10.1073/pnas.0400208101. Epub 2004 Mar 4. Proc Natl Acad Sci U S A. 2004. PMID: 15001711 Free PMC article.
Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation.
Gupta M, Kaur G. Gupta M, et al. BMC Complement Altern Med. 2019 Aug 15;19(1):217. doi: 10.1186/s12906-019-2635-0. BMC Complement Altern Med. 2019. PMID: 31416451 Free PMC article.
Opposite effects of early maternal deprivation on neurogenesis in male versus female rats.
Oomen CA, Girardi CE, Cahyadi R, Verbeek EC, Krugers H, Joëls M, Lucassen PJ. Oomen CA, et al. PLoS One. 2009;4(1):e3675. doi: 10.1371/journal.pone.0003675. Epub 2009 Jan 30. PLoS One. 2009. PMID: 19180242 Free PMC article.
GSK3β: A Master Player in Depressive Disorder Pathogenesis and Treatment Responsiveness.
Duda P, Hajka D, Wójcicka O, Rakus D, Gizak A. Duda P, et al. Cells. 2020 Mar 16;9(3):727. doi: 10.3390/cells9030727. Cells. 2020. PMID: 32188010 Free PMC article. Review.

Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus - PubMed (original) (raw)