RecQ helicases: caretakers of the genome - PubMed (original) (raw)

Review

doi: 10.1038/nrc1012.

Affiliations

• PMID: 12612652
• DOI: 10.1038/nrc1012

Review

RecQ helicases: caretakers of the genome

Ian D Hickson. Nat Rev Cancer. 2003 Mar.

Abstract

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders--Bloom's syndrome--is uniquely associated with a predisposition to cancers of all types. So how do RecQ helicases protect against cancer? They seem to maintain genomic stability by functioning at the interface between DNA replication and DNA repair.

PubMed Disclaimer

Similar articles

• Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.
  Furuichi Y. Furuichi Y. Ann N Y Acad Sci. 2001 Apr;928:121-31. doi: 10.1111/j.1749-6632.2001.tb05642.x. Ann N Y Acad Sci. 2001. PMID: 11795503 Review.
• Human diseases deficient in RecQ helicases.
  Harrigan JA, Bohr VA. Harrigan JA, et al. Biochimie. 2003 Nov;85(11):1185-93. doi: 10.1016/j.biochi.2003.10.006. Biochimie. 2003. PMID: 14726023
• RecQ family helicases: roles as tumor suppressor proteins.
  Nakayama H. Nakayama H. Oncogene. 2002 Dec 16;21(58):9008-21. doi: 10.1038/sj.onc.1205959. Oncogene. 2002. PMID: 12483516 Review.
• DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
  Mohaghegh P, Hickson ID. Mohaghegh P, et al. Hum Mol Genet. 2001 Apr;10(7):741-6. doi: 10.1093/hmg/10.7.741. Hum Mol Genet. 2001. PMID: 11257107 Review.
• Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.
  Killoran MP, Keck JL. Killoran MP, et al. Nucleic Acids Res. 2006;34(15):4098-105. doi: 10.1093/nar/gkl538. Epub 2006 Aug 25. Nucleic Acids Res. 2006. PMID: 16935877 Free PMC article. Review.

Cited by

• Single-strand DNA-binding protein suppresses illegitimate recombination in Escherichia coli, acting in synergy with RecQ helicase.
  Feliciello I, Ljubić S, Đermić E, Ivanković S, Zahradka D, Đermić D. Feliciello I, et al. Sci Rep. 2024 Sep 3;14(1):20476. doi: 10.1038/s41598-024-70817-5. Sci Rep. 2024. PMID: 39227621 Free PMC article.
• Functional correlation between WRN and SAMHD1 in DNA end-resection.
  Perdichizzi B, Pichierri P. Perdichizzi B, et al. MicroPubl Biol. 2024 May 2;2024:10.17912/micropub.biology.001157. doi: 10.17912/micropub.biology.001157. eCollection 2024. MicroPubl Biol. 2024. PMID: 38764946 Free PMC article.
• TFIP11 promotes replication fork reversal to preserve genome stability.
  Chen J, Wu M, Yang Y, Ruan C, Luo Y, Song L, Wu T, Huang J, Yang B, Liu T. Chen J, et al. Nat Commun. 2024 Feb 10;15(1):1262. doi: 10.1038/s41467-024-45684-3. Nat Commun. 2024. PMID: 38341452 Free PMC article.
• Insights into common fragile site instability: DNA replication challenges at DNA repeat sequences.
  Irony-Tur Sinai M, Kerem B. Irony-Tur Sinai M, et al. Emerg Top Life Sci. 2023 Dec 14;7(3):277-287. doi: 10.1042/ETLS20230023. Emerg Top Life Sci. 2023. PMID: 37876349 Free PMC article.
• Repair and tolerance of DNA damage at the replication fork: A structural perspective.
  Eichman BF. Eichman BF. Curr Opin Struct Biol. 2023 Aug;81:102618. doi: 10.1016/j.sbi.2023.102618. Epub 2023 Jun 1. Curr Opin Struct Biol. 2023. PMID: 37269798 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database