Angiogenesis in hematologic malignancies - PubMed (original) (raw)

Review

Angiogenesis in hematologic malignancies

T M Moehler et al. Crit Rev Oncol Hematol. 2003 Mar.

Abstract

Angiogenesis is defined as the formation of new capillaries from preexisting blood vessels and plays an important role in the progression of solid tumors. Recently a similar relationship has been described in several hematologic malignancies. Expression of the angiogenic peptides vascular endothelial growth factor (VEGF) and basic fibroblast growth factor correlates with clinical characteristics in leukemia and non-Hodgkin's-lymphoma and the serum/plasma concentrations serve as predictors of poor prognosis. Increased bone marrow microvessels in multiple myeloma (MM) are correlated with decreased overall survival. Thalidomide which has antiangiogenic effects and direct cytotoxic effects was found to be effective in MM, myelodysplastic syndrome and acute myeloid leukemia (AML). Preliminary data indicate activity of VEGF-tyrosine kinase inhibitors in AML. Clinical research is now aimed at testing antiangiogenic treatment strategies in several hematologic neoplasms as well as identifying the best candidate patients for specific approaches.

PubMed Disclaimer

Similar articles

• Antiangiogenic therapy in hematologic malignancies.
  Moehler TM, Hillengass J, Goldschmidt H, Ho AD. Moehler TM, et al. Curr Pharm Des. 2004;10(11):1221-34. doi: 10.2174/1381612043452587. Curr Pharm Des. 2004. PMID: 15078137 Review.
• [Angiogenesis and hematologic malignancy].
  Zini JM, Tobelem G. Zini JM, et al. Bull Cancer. 2007 Jul;94 Spec No:S241-6. Bull Cancer. 2007. PMID: 17846010 Review. French.
• [Angiogenesis in patients with hematologic malignancies].
  Mesters RM, Padró T, Steins M, Bieker R, Retzlaff S, Kessler T, Kienast J, Berdel WE. Mesters RM, et al. Onkologie. 2001 Sep;24 Suppl 5:75-80. doi: 10.1159/000055192. Onkologie. 2001. PMID: 11600818 Review. German.
• Angiogenesis in hematologic malignancies.
  Moehler TM, Neben K, Ho AD, Goldschmidt H. Moehler TM, et al. Ann Hematol. 2001 Dec;80(12):695-705. doi: 10.1007/s00277-001-0398-3. Epub 2001 Nov 14. Ann Hematol. 2001. PMID: 11797109 Review.
• Angiogenesis and antiangiogenic therapy in hematologic malignancies.
  Dong X, Han ZC, Yang R. Dong X, et al. Crit Rev Oncol Hematol. 2007 May;62(2):105-18. doi: 10.1016/j.critrevonc.2006.11.006. Epub 2006 Dec 22. Crit Rev Oncol Hematol. 2007. PMID: 17188504 Review.

Cited by

• The role of vascular endothelial growth factor and matrix metalloproteinases in canine lymphoma: in vivo and in vitro study.
  Aricò A, Giantin M, Gelain ME, Riondato F, Comazzi S, Rütgen BC, Essler SE, Dacasto M, Castagnaro M, Aresu L. Aricò A, et al. BMC Vet Res. 2013 May 3;9:94. doi: 10.1186/1746-6148-9-94. BMC Vet Res. 2013. PMID: 23641796 Free PMC article.
• Nonirradiated NOD/SCID-human chimeric animal model for primary human multiple myeloma: a potential in vivo culture system.
  Huang SY, Tien HF, Su FH, Hsu SM. Huang SY, et al. Am J Pathol. 2004 Feb;164(2):747-56. doi: 10.1016/S0002-9440(10)63162-8. Am J Pathol. 2004. PMID: 14742278 Free PMC article.
• Changes in magnetic resonance bone marrow angiogenesis on day 7 after induction chemotherapy can predict outcome of acute myeloid leukemia.
  Hou HA, Shih TT, Liu CY, Chen BB, Tang JL, Yao M, Huang SY, Chou WC, Hsu CY, Tien HF. Hou HA, et al. Haematologica. 2010 Aug;95(8):1420-4. doi: 10.3324/haematol.2009.019364. Epub 2010 Mar 10. Haematologica. 2010. PMID: 20220062 Free PMC article. Clinical Trial.
• Effects of spironolactone and losartan on diabetic nephropathy in a type 2 diabetic rat model.
  Lee MY, Shim MS, Kim BH, Hong SW, Choi R, Lee EY, Nam SM, Kim GW, Shin JY, Shin YG, Chung CH. Lee MY, et al. Diabetes Metab J. 2011 Apr;35(2):130-7. doi: 10.4093/dmj.2011.35.2.130. Epub 2011 Apr 30. Diabetes Metab J. 2011. PMID: 21738895 Free PMC article.
• From nutraceuticals to pharmaceuticals to nanopharmaceuticals: a case study in angiogenesis modulation during oxidative stress.
  Mousa SA, Bharali DJ, Armstrong D. Mousa SA, et al. Mol Biotechnol. 2007 Sep;37(1):72-80. doi: 10.1007/s12033-007-0064-7. Mol Biotechnol. 2007. PMID: 17914168 Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database