Arterial calcification in diabetes - PubMed (original) (raw)

Review

Arterial calcification in diabetes

Neal X Chen et al. Curr Diab Rep. 2003 Feb.

Abstract

Diabetes is associated with an increased prevalence of atherosclerotic vascular disease and cardiovascular mortality. In diabetic patients, medial calcification appears to be a strong independent predictor of cardiovascular mortality, it occurs particularly in those with neuropathy. Recent evidence suggests that medial calcification in diabetes is an active, cell-mediated process, similar to that observed in patients with end-stage renal disease (ESRD), in which vascular smooth muscle cells (VSMCs) express a number of bone matrix proteins that act to either facilitate or regulate the calcification process. Several bone-associated proteins (e.g., osteopontin, bone sialoprotein, alkaline phosphatase, type 1 collagen, osteocalcin) have been demonstrated in histologic sections of vessels obtained from patients with diabetes or ESRD. In in vitro experiments, high glucose induced cell proliferation and expression of osteopontin in cultured VSMCs. Hypoxia had additive effects of hyperglycemia on VSMCs. In addition, uremic serum upregulates osteoblast transcription factor Cbfa 1 and osteopontin expression in cultured VSMCs. The pathogenesis of vascular calcification in diabetes is not completely understood, although high glucose and other potential factors may play an important role by transforming VSMCs into osteoblast-like cells. Further understanding of the mechanism by which diabetes induces this complication is needed to design effective therapeutic strategies to intervene with this process.

PubMed Disclaimer

Similar articles

• Vascular calcification in dialysis patients: pathogenesis and consequences.
  Reslerova M, Moe SM. Reslerova M, et al. Am J Kidney Dis. 2003 Mar;41(3 Suppl 1):S96-9. doi: 10.1053/ajkd.2003.50094. Am J Kidney Dis. 2003. PMID: 12612962 Review.
• Vascular calcification in chronic kidney disease.
  Chen NX, Moe SM. Chen NX, et al. Semin Nephrol. 2004 Jan;24(1):61-8. doi: 10.1053/j.semnephrol.2003.08.014. Semin Nephrol. 2004. PMID: 14730511 Review.
• Uremic vasculopathy.
  Moe SM. Moe SM. Semin Nephrol. 2004 Sep;24(5):413-6. doi: 10.1016/j.semnephrol.2004.06.015. Semin Nephrol. 2004. PMID: 15490401 Review.
• Vascular calcification in end stage renal disease.
  Moe SM, Chen NX. Moe SM, et al. Clin Calcium. 2002 Oct;12(10):1417-22. Clin Calcium. 2002. PMID: 15775441
• High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells.
  Chen NX, Duan D, O'Neill KD, Moe SM. Chen NX, et al. Nephrol Dial Transplant. 2006 Dec;21(12):3435-42. doi: 10.1093/ndt/gfl429. Epub 2006 Sep 27. Nephrol Dial Transplant. 2006. PMID: 17005530

Cited by

• CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification.
  Zhao Y, Yang Y, Wu X, Zhang L, Cai X, Ji J, Chen S, Vera A, Boström KI, Yao Y. Zhao Y, et al. JCI Insight. 2024 Mar 8;9(5):e176065. doi: 10.1172/jci.insight.176065. JCI Insight. 2024. PMID: 38456502 Free PMC article.
• The KL genetic polymorphisms Associated with type 2 diabetes Mellitus.
  Jin HS, Jung D. Jin HS, et al. Indian J Clin Biochem. 2023 Jul;38(3):385-392. doi: 10.1007/s12291-022-01057-5. Epub 2022 Aug 10. Indian J Clin Biochem. 2023. PMID: 37234182 Free PMC article.
• GSK3β Inhibition Reduced Vascular Calcification in Ins2Akita/+ Mice.
  Boström KI, Qiao X, Zhao Y, Wu X, Zhang L, Ma JA, Ji J, Cai X, Yao Y. Boström KI, et al. Int J Mol Sci. 2023 Mar 22;24(6):5971. doi: 10.3390/ijms24065971. Int J Mol Sci. 2023. PMID: 36983045 Free PMC article.
• BMF-AS1/BMF Promotes Diabetic Vascular Calcification and Aging both In Vitro and In Vivo.
  Lin X, Xiang QY, Li S, Song WL, Wang YJ, Ni YQ, Zhao Y, Li C, Wang Y, Li HH, Liang Z, Zhan JK, Liu YS. Lin X, et al. Aging Dis. 2023 Feb 1;14(1):170-183. doi: 10.14336/AD.2022.0427. eCollection 2023 Feb 1. Aging Dis. 2023. PMID: 36818559 Free PMC article.
• Medial artery calcification in peripheral artery disease.
  Kim TI, Guzman RJ. Kim TI, et al. Front Cardiovasc Med. 2023 Jan 26;10:1093355. doi: 10.3389/fcvm.2023.1093355. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 36776265 Free PMC article. Review.

References

1. 1. Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2112-8 - PubMed
2. 1. Circ Res. 2000 Sep 29;87(7):E10-7 - PubMed
3. 1. Diabetes. 2001 Jun;50(6):1482-90 - PubMed
4. 1. Br Med J (Clin Res Ed). 1982 Mar 27;284(6320):928-30 - PubMed
5. 1. Cell. 1997 May 30;89(5):755-64 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Medical

  • MedlinePlus Consumer Health Information
  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program