The epidermal growth factor system in Caenorhabditis elegans - PubMed (original) (raw)
Review
The epidermal growth factor system in Caenorhabditis elegans
Nadeem Moghal et al. Exp Cell Res. 2003.
Abstract
The single known epidermal growth factor-like growth factor and single epidermal growth factor receptor in Caenorhabditis elegans mediate two types of processes, each via a distinct signal transduction pathway. Several instances of cell fate specification during organogenesis require the RAS-MAP kinase pathway, as well as multiple nuclear factors. By contrast, appropriate myoepithelial contractions during ovulation involve IP3-mediated signal transduction. Positive modulators of the RAS pathway include KSR, SUR-8, phosphatase PP2A, and a zinc cation diffusion facilitator. Negative regulators of the RAS pathway include homologs of CBL, GAP-1, ACK, and MAP kinase phosphatase, while negative regulators of the IP3 pathway are enzymes that modify IP3. In addition to its stimulation of RAS activity, the GRB2 homolog SEM-5 acts negatively on both signaling pathways, as does the Ack-related kinase ARK-1.
Similar articles
- Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5.
Worby C, Margolis B. Worby C, et al. Sci STKE. 2000 Dec 19;2000(63):pe2. doi: 10.1126/stke.2000.63.pe2. Sci STKE. 2000. PMID: 11752629 Review. - C. elegans vulval development as a model system to study the cancer biology of EGFR signaling.
Chang C, Sternberg PW. Chang C, et al. Cancer Metastasis Rev. 1999;18(2):203-13. doi: 10.1023/a:1006317206443. Cancer Metastasis Rev. 1999. PMID: 10728984 Review. - Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.
Yoder JH, Chong H, Guan KL, Han M. Yoder JH, et al. EMBO J. 2004 Jan 14;23(1):111-9. doi: 10.1038/sj.emboj.7600025. Epub 2003 Dec 11. EMBO J. 2004. PMID: 14685271 Free PMC article. - LET-23-mediated signal transduction during Caenorhabditis elegans development.
Sternberg PW, Lesa G, Lee J, Katz WS, Yoon C, Clandinin TR, Huang LS, Chamberlin HM, Jongeward G. Sternberg PW, et al. Mol Reprod Dev. 1995 Dec;42(4):523-8. doi: 10.1002/mrd.1080420422. Mol Reprod Dev. 1995. PMID: 8607985 Review. - The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.
Schutzman JL, Borland CZ, Newman JC, Robinson MK, Kokel M, Stern MJ. Schutzman JL, et al. Mol Cell Biol. 2001 Dec;21(23):8104-16. doi: 10.1128/MCB.21.23.8104-8116.2001. Mol Cell Biol. 2001. PMID: 11689700 Free PMC article.
Cited by
- Overactive EGF signaling suppresses a C. elegans pnc-1 egg-laying phenotype independent of known signaling mediators.
Crook M, Hanna-Rose W. Crook M, et al. MicroPubl Biol. 2021 Oct 4;2021:10.17912/micropub.biology.000482. doi: 10.17912/micropub.biology.000482. eCollection 2021. MicroPubl Biol. 2021. PMID: 34723146 Free PMC article. - Outstanding questions in developmental ERK signaling.
Patel AL, Shvartsman SY. Patel AL, et al. Development. 2018 Jul 26;145(14):dev143818. doi: 10.1242/dev.143818. Development. 2018. PMID: 30049820 Free PMC article. Review. - C. elegans SMA-10 regulates BMP receptor trafficking.
Gleason RJ, Vora M, Li Y, Kane NS, Liao K, Padgett RW. Gleason RJ, et al. PLoS One. 2017 Jul 13;12(7):e0180681. doi: 10.1371/journal.pone.0180681. eCollection 2017. PLoS One. 2017. PMID: 28704415 Free PMC article. - Discovering Functional ERK Substrates Regulating Caenorhabditis elegans Germline Development.
Chen JJ, Arur S. Chen JJ, et al. Methods Mol Biol. 2017;1487:317-335. doi: 10.1007/978-1-4939-6424-6_24. Methods Mol Biol. 2017. PMID: 27924578 Free PMC article. - Epidermal Growth Factor Receptor Cell Survival Signaling Requires Phosphatidylcholine Biosynthesis.
Crook M, Upadhyay A, Ido LJ, Hanna-Rose W. Crook M, et al. G3 (Bethesda). 2016 Nov 8;6(11):3533-3540. doi: 10.1534/g3.116.034850. G3 (Bethesda). 2016. PMID: 27605519 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous