Anti-inflammatory strategies for the treatment of sepsis - PubMed (original) (raw)

Review

Anti-inflammatory strategies for the treatment of sepsis

Niels C Riedemann et al. Expert Opin Biol Ther. 2003 Apr.

Abstract

Sepsis leads to an overwhelming inflammatory response of the host and is usually accompanied by well-known clinical symptoms (fever, tachycardia, leukocytosis, and so on) and the accompanying systemic inflammatory response syndrome (SIRS). Accordingly, most efforts to develop treatment strategies for sepsis have focused on those designed to counteract overactivation of the inflammatory system. Despite intensive research into identifying targets in sepsis, most of the resulting clinical trials have been based on experimental data and have resulted in no beneficial effects (i.e., survival). Recombinant activated protein C (APC) represents the first treatment that has led to restricted approval for use in sepsis in the USA and worldwide. This article reviews approaches to anti-inflammatory treatment in sepsis and provides an outlook into ongoing clinical trials as well as new treatments that have not yet been evaluated in the clinical setting.

PubMed Disclaimer

Cited by

BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes.
Dang CP, Issara-Amphorn J, Charoensappakit A, Udompornpitak K, Bhunyakarnjanarat T, Saisorn W, Sae-Khow K, Leelahavanichkul A. Dang CP, et al. J Innate Immun. 2021;13(6):359-375. doi: 10.1159/000516348. Epub 2021 Jun 1. J Innate Immun. 2021. PMID: 34062536 Free PMC article.
Over-expression of miR-223 induces M2 macrophage through glycolysis alteration and attenuates LPS-induced sepsis mouse model, the cell-based therapy in sepsis.
Dang CP, Leelahavanichkul A. Dang CP, et al. PLoS One. 2020 Jul 13;15(7):e0236038. doi: 10.1371/journal.pone.0236038. eCollection 2020. PLoS One. 2020. PMID: 32658933 Free PMC article.
Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination.
Angeletti S, Dicuonzo G, Fioravanti M, De Cesaris M, Fogolari M, Lo Presti A, Ciccozzi M, De Florio L. Angeletti S, et al. Dis Markers. 2015;2015:951532. doi: 10.1155/2015/951532. Epub 2015 Nov 9. Dis Markers. 2015. PMID: 26635427 Free PMC article.
Hydrogen gas presents a promising therapeutic strategy for sepsis.
Xie K, Liu L, Yu Y, Wang G. Xie K, et al. Biomed Res Int. 2014;2014:807635. doi: 10.1155/2014/807635. Epub 2014 Apr 16. Biomed Res Int. 2014. PMID: 24829918 Free PMC article. Review.
Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?
Gentile LF, Cuenca AG, Vanzant EL, Efron PA, McKinley B, Moore F, Moldawer LL. Gentile LF, et al. Methods. 2013 May 15;61(1):3-9. doi: 10.1016/j.ymeth.2013.04.024. Epub 2013 May 11. Methods. 2013. PMID: 23669589 Free PMC article. Review.

Anti-inflammatory strategies for the treatment of sepsis - PubMed (original) (raw)