Application of the lod method to the detection of linkage between a quantitative trait and a qualitative marker: a simulation experiment - PubMed (original) (raw)

• PMID: 1266848
• PMCID: PMC1684928

Application of the lod method to the detection of linkage between a quantitative trait and a qualitative marker: a simulation experiment

K Lange et al. Am J Hum Genet. 1976 Mar.

Abstract

Simulation experiments were performed to assess the power of the lod method for detecting linkage between a quantitative trait and a qualitative marker. Using family data on the Amy2-Duffy linkage, it was found that linkage detection is feasible in certain limited circumstances. The same qualitative data yielded no evidence for a significant difference in male and female recombination fractions.

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References

1. 1. Ann Hum Genet. 1975 Jan;38(3):341-50 - PubMed
2. 1. Ann Hum Genet. 1975 Jul;39(1):67-87 - PubMed
3. 1. Ann Hum Genet. 1975 May;38(4):439-49 - PubMed
4. 1. Behav Genet. 1972 Mar;2(1):3-19 - PubMed
5. 1. Am J Hum Genet. 1974 Sep;26(5):588-97 - PubMed

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