Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells - PubMed (original) (raw)
. 2003 May 20;105(1):7-13.
doi: 10.1002/ijc.11012.
Affiliations
- PMID: 12672023
- DOI: 10.1002/ijc.11012
Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells
Christèle Bisson et al. Int J Cancer. 2003.
Abstract
The membrane type-1 matrix metalloproteinase (MT1-MMP), a protease originally identified in breast carcinoma, is characterized by its capacity to activate other MMPs (MMP-2 and MMP-13) and to degrade extracellular matrix. Our study was undertaken to localize and identify the MT1-MMP expressing cells in human breast adenocarcinomas. A textural analysis of images obtained by immunohistochemistry and in situ hybridization showed precisely the co-expression of alpha smooth muscle actin (alphaSM actin) and MT1-MMP in myofibroblasts. MT1-MMP expression is confined to myofibroblasts in close contact with tumor cells. In sharp contrast, the expression of MMP-2 was more widely distributed in both alphaSM actin positive and negative cells close to and at distance from cancer cell clusters. Our in vitro observations are consistent with the higher level of MT1-MMP expression and of MMP-2 activation observed in alphaSM actin positive fibroblasts derived from breast tumors, as compared to normal breast fibroblasts. Collectively, these results implicate myofibroblasts as major producer of MT1-MMP in breast cancer and emphasize the importance of stromal-epithelial cell interactions in their progression.
Copyright 2003 Wiley-Liss, Inc.
Similar articles
- Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Elnemr A, Yonemura Y, Bandou E, Kinoshita K, Kawamura T, Takahashi S, Tochiori S, Endou Y, Sasaki T. Elnemr A, et al. Gastric Cancer. 2003;6(1):30-8. doi: 10.1007/s101200300004. Gastric Cancer. 2003. PMID: 12673424 - Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.
Lafleur MA, Drew AF, de Sousa EL, Blick T, Bills M, Walker EC, Williams ED, Waltham M, Thompson EW. Lafleur MA, et al. Int J Cancer. 2005 Apr 20;114(4):544-54. doi: 10.1002/ijc.20763. Int J Cancer. 2005. PMID: 15551360 - PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts.
Ottino P, He J, Axelrad TW, Bazan HE. Ottino P, et al. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):487-96. doi: 10.1167/iovs.04-0852. Invest Ophthalmol Vis Sci. 2005. PMID: 15671273 - Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review.
Basset P, Wolf C, Chambon P. Basset P, et al. Breast Cancer Res Treat. 1993;24(3):185-93. doi: 10.1007/BF01833259. Breast Cancer Res Treat. 1993. PMID: 8435474 Review. - Matrix-metalloproteinases in bronchopulmonary carcinomas.
Martinella-Catusse C, Nawrocki B, Gilles C, Birembaut P, Polette M. Martinella-Catusse C, et al. Histol Histopathol. 1999 Jul;14(3):839-43. doi: 10.14670/HH-14.839. Histol Histopathol. 1999. PMID: 10425554 Review.
Cited by
- Fibroblast Growth Factor-2 and the Invasive Potential in Urothelial Malignancies of the Bladder.
Popov H, Stoyanov GS, Ghenev P. Popov H, et al. Cureus. 2023 Jan 24;15(1):e34147. doi: 10.7759/cureus.34147. eCollection 2023 Jan. Cureus. 2023. PMID: 36843751 Free PMC article. - May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?
Shrestha B, Bajracharya D, Byatnal AA, Kamath A, Radhakrishnan R. Shrestha B, et al. Pathol Oncol Res. 2017 Jan;23(1):197-206. doi: 10.1007/s12253-016-0149-3. Epub 2016 Nov 16. Pathol Oncol Res. 2017. PMID: 27853937 - Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment.
McDonald LT, Russell DL, Kelly RR, Xiong Y, Motamarry A, Patel RK, Jones JA, Watson PM, Turner DP, Watson DK, Soloff AC, Findlay VJ, LaRue AC. McDonald LT, et al. Neoplasia. 2015 May;17(5):434-48. doi: 10.1016/j.neo.2015.04.004. Neoplasia. 2015. PMID: 26025666 Free PMC article. - p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.
Lodillinsky C, Infante E, Guichard A, Chaligné R, Fuhrmann L, Cyrta J, Irondelle M, Lagoutte E, Vacher S, Bonsang-Kitzis H, Glukhova M, Reyal F, Bièche I, Vincent-Salomon A, Chavrier P. Lodillinsky C, et al. Oncogene. 2016 Jan 21;35(3):344-57. doi: 10.1038/onc.2015.87. Epub 2015 Apr 20. Oncogene. 2016. PMID: 25893299 - Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer.
O'Connor JW, Gomez EW. O'Connor JW, et al. Clin Transl Med. 2014 Jul 15;3:23. doi: 10.1186/2001-1326-3-23. eCollection 2014. Clin Transl Med. 2014. PMID: 25097726 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous