Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disease prevalence - PubMed (original) (raw)
Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disease prevalence
Judith A Staples et al. Environ Health Perspect. 2003 Apr.
Abstract
The apparent immune-suppressive effect of ultraviolet radiation (UVR) has suggested that this environmental exposure may influence the development of immune-related disorders. Self-reported prevalence rates of type 1 diabetes mellitus, rheumatoid arthritis (RA), eczema/dermatitis, and asthma, from the 1995 Australian National Health Survey, were therefore examined by latitude and ambient level of UVR. A positive association of type 1 diabetes mellitus prevalence was found with both increasing southern latitude of residence (r = 0.77; p = 0.026) and decreasing regional annual ambient UVR (r= -0.80; p = 0.018); a 3-fold increase in prevalence from the northernmost region to the southernmost region was evident. In contrast, asthma correlated negatively with latitude (r = -0.72; p = 0.046), although the change in asthma prevalence from the north to the south of Australia was only 0.7-fold. For both RA and eczema/dermatitis, there were no statistically significant associations between latitude/UVR and disease prevalence. These ecologic data provide some support for a previously proposed beneficial effect of UVR on T-helper 1-mediated autoimmune disorders such as type 1 diabetes. The inverse association of type 1 diabetes prevalence with UVR is consistent with that previously reported for another autoimmune disease, multiple sclerosis, in Australia, and also with type 1 diabetes latitudinal gradients in the Northern Hemisphere. The finding also accords with photoimmunologic evidence of UVR-induced immunosuppression and may suggest a beneficial effect of UVR in reducing the incidence of such autoimmune conditions. In light of this study, analytic epidemiologic studies investigating risk of immune disorders in relation to personal UVR exposure in humans are required.
Similar articles
- UVR, vitamin D and three autoimmune diseases--multiple sclerosis, type 1 diabetes, rheumatoid arthritis.
Ponsonby AL, Lucas RM, van der Mei IA. Ponsonby AL, et al. Photochem Photobiol. 2005 Nov-Dec;81(6):1267-75. doi: 10.1562/2005-02-15-IR-441. Photochem Photobiol. 2005. PMID: 15971932 Review. - The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study.
Hughes AM, Lucas RM, Ponsonby AL, Chapman C, Coulthard A, Dear K, Dwyer T, Kilpatrick TJ, McMichael AJ, Pender MP, Taylor BV, Valery P, van der Mei IA, Williams D. Hughes AM, et al. Pediatr Allergy Immunol. 2011 May;22(3):327-33. doi: 10.1111/j.1399-3038.2010.01099.x. Epub 2010 Sep 30. Pediatr Allergy Immunol. 2011. PMID: 20880353 - Regional variation in multiple sclerosis prevalence in Australia and its association with ambient ultraviolet radiation.
van der Mei IA, Ponsonby AL, Blizzard L, Dwyer T. van der Mei IA, et al. Neuroepidemiology. 2001 Aug;20(3):168-74. doi: 10.1159/000054783. Neuroepidemiology. 2001. PMID: 11490162 - Ultraviolet radiation and autoimmune disease: insights from epidemiological research.
Ponsonby AL, McMichael A, van der Mei I. Ponsonby AL, et al. Toxicology. 2002 Dec 27;181-182:71-8. doi: 10.1016/s0300-483x(02)00257-3. Toxicology. 2002. PMID: 12505287 Review. - The relationship between ambient ultraviolet radiation (UVR) and objectively measured personal UVR exposure dose is modified by season and latitude.
Sun J, Lucas RM, Harrison S, van der Mei I, Armstrong BK, Nowak M, Brodie A, Kimlin MG. Sun J, et al. Photochem Photobiol Sci. 2014 Dec;13(12):1711-8. doi: 10.1039/c4pp00322e. Epub 2014 Oct 14. Photochem Photobiol Sci. 2014. PMID: 25311529
Cited by
- The Prevalence and Clinical Phenotypes of Cluster Headache in Relation with Latitude.
Liaw YC, Chen SP, Wang SJ. Liaw YC, et al. Curr Pain Headache Rep. 2024 May;28(5):427-438. doi: 10.1007/s11916-024-01229-3. Epub 2024 Mar 5. Curr Pain Headache Rep. 2024. PMID: 38441794 Free PMC article. Review. - Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review.
Ghaseminejad-Raeini A, Ghaderi A, Sharafi A, Nematollahi-Sani B, Moossavi M, Derakhshani A, Sarab GA. Ghaseminejad-Raeini A, et al. Front Immunol. 2023 Jul 14;14:950465. doi: 10.3389/fimmu.2023.950465. eCollection 2023. Front Immunol. 2023. PMID: 37520529 Free PMC article. Review. - Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19.
Cutolo M, Smith V, Paolino S, Gotelli E. Cutolo M, et al. Nat Rev Rheumatol. 2023 May;19(5):265-287. doi: 10.1038/s41584-023-00944-2. Epub 2023 Mar 28. Nat Rev Rheumatol. 2023. PMID: 36977791 Free PMC article. Review. - The position of geochemical variables as causal co-factors of diseases of unknown aetiology.
Davies TC. Davies TC. SN Appl Sci. 2022;4(8):236. doi: 10.1007/s42452-022-05113-w. Epub 2022 Jul 27. SN Appl Sci. 2022. PMID: 35909942 Free PMC article. Review. - Association of the incidence of atopic dermatitis until 3 years old with climate conditions in the first 6 months of life: Japan Environment and Children's Study (JECS).
Yokomichi H, Mochizuki M, Shinohara R, Kushima M, Horiuchi S, Kojima R, Ooka T, Akiyama Y, Miyake K, Otawa S, Yamagata Z; Japan Environment and Children’s Study Group. Yokomichi H, et al. PLoS One. 2022 May 6;17(5):e0268204. doi: 10.1371/journal.pone.0268204. eCollection 2022. PLoS One. 2022. PMID: 35522685 Free PMC article.
References
- N Engl J Med. 1999 Dec 30;341(27):2068-74 - PubMed
- Lancet. 2001 Jun 23;357(9273):2012-6 - PubMed
- Immunology. 1999 Jul;97(3):506-14 - PubMed
- J Med Microbiol. 2000 Apr;49(4):305-11 - PubMed
- Brain. 2000 May;123 ( Pt 5):968-74 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical