Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen - PubMed (original) (raw)
Case Reports
doi: 10.1038/sj.bmt.1703872.
A Ibatici, E Berti, P Morandi, E Longhi, L Venegoni, M Corbellino, C Annaloro, L Robbiolo, A Della Volpe, E Alessi, G Lambertenghi Deliliers
Affiliations
- PMID: 12692606
- DOI: 10.1038/sj.bmt.1703872
Case Reports
Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen
D Soligo et al. Bone Marrow Transplant. 2003 Apr.
Abstract
Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
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