The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities - PubMed (original) (raw)

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells.

Souter MNT, Awad W, Li S, Pediongco TJ, Meehan BS, Meehan LJ, Tian Z, Zhao Z, Wang H, Nelson A, Le Nours J, Khandokar Y, Praveena T, Wubben J, Lin J, Sullivan LC, Lovrecz GO, Mak JYW, Liu L, Kostenko L, Kedzierska K, Corbett AJ, Fairlie DP, Brooks AG, Gherardin NA, Uldrich AP, Chen Z, Rossjohn J, Godfrey DI, McCluskey J, Pellicci DG, Eckle SBG. Souter MNT, et al. J Exp Med. 2022 Sep 5;219(9):e20210828. doi: 10.1084/jem.20210828. Epub 2022 Aug 26. J Exp Med. 2022. PMID: 36018322 Free PMC article.