Dynactin: coordinating motors with opposite inclinations - PubMed (original) (raw)

Review

. 2003 Apr 15;13(8):R320-2.

Affiliations

• PMID: 12699645

Free article

Review

Dynactin: coordinating motors with opposite inclinations

Steven P Gross. Curr Biol. 2003.

Free article

Abstract

In eukaryotic cells, many organelles are transported bidirectionally along microtubules by kinesin and dynein. These opposite-polarity motors appear to be coordinated to avoid interfering with each other's function. New work has provided the first molecular insight into how such coordination might occur.

PubMed Disclaimer

Similar articles

• Dynein, dynactin, and kinesin II's interaction with microtubules is regulated during bidirectional organelle transport.
  Reese EL, Haimo LT. Reese EL, et al. J Cell Biol. 2000 Oct 2;151(1):155-66. doi: 10.1083/jcb.151.1.155. J Cell Biol. 2000. PMID: 11018061 Free PMC article. Retracted.
• Bidirectional transport along microtubules.
  Welte MA. Welte MA. Curr Biol. 2004 Jul 13;14(13):R525-37. doi: 10.1016/j.cub.2004.06.045. Curr Biol. 2004. PMID: 15242636 Review.
• Coordination of opposite-polarity microtubule motors.
  Gross SP, Welte MA, Block SM, Wieschaus EF. Gross SP, et al. J Cell Biol. 2002 Feb 18;156(4):715-24. doi: 10.1083/jcb.200109047. Epub 2002 Feb 28. J Cell Biol. 2002. PMID: 11854311 Free PMC article.
• Bidirectional transport of organelles: unity and struggle of opposing motors.
  Bryantseva SA, Zhapparova ON. Bryantseva SA, et al. Cell Biol Int. 2012 Jan;36(1):1-6. doi: 10.1042/CBI20110413. Cell Biol Int. 2012. PMID: 22142363 Review.
• Dynactin is required for bidirectional organelle transport.
  Deacon SW, Serpinskaya AS, Vaughan PS, Lopez Fanarraga M, Vernos I, Vaughan KT, Gelfand VI. Deacon SW, et al. J Cell Biol. 2003 Feb 3;160(3):297-301. doi: 10.1083/jcb.200210066. Epub 2003 Jan 27. J Cell Biol. 2003. PMID: 12551954 Free PMC article.

Cited by

• Dynactin is required to maintain nuclear position within postmitotic Drosophila photoreceptor neurons.
  Whited JL, Cassell A, Brouillette M, Garrity PA. Whited JL, et al. Development. 2004 Oct;131(19):4677-86. doi: 10.1242/dev.01366. Epub 2004 Aug 25. Development. 2004. PMID: 15329347 Free PMC article.
• Bidirectional cargo transport: moving beyond tug of war.
  Hancock WO. Hancock WO. Nat Rev Mol Cell Biol. 2014 Sep;15(9):615-28. doi: 10.1038/nrm3853. Epub 2014 Aug 16. Nat Rev Mol Cell Biol. 2014. PMID: 25118718 Free PMC article. Review.
• Golgi positioning.
  Yadav S, Linstedt AD. Yadav S, et al. Cold Spring Harb Perspect Biol. 2011 May 1;3(5):a005322. doi: 10.1101/cshperspect.a005322. Cold Spring Harb Perspect Biol. 2011. PMID: 21504874 Free PMC article. Review.
• The reciprocal coordination and mechanics of molecular motors in living cells.
  Laib JA, Marin JA, Bloodgood RA, Guilford WH. Laib JA, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3190-5. doi: 10.1073/pnas.0809849106. Epub 2009 Feb 12. Proc Natl Acad Sci U S A. 2009. PMID: 19221028 Free PMC article.
• The Drosophila BEACH family protein, blue cheese, links lysosomal axon transport with motor neuron degeneration.
  Lim A, Kraut R. Lim A, et al. J Neurosci. 2009 Jan 28;29(4):951-63. doi: 10.1523/JNEUROSCI.2582-08.2009. J Neurosci. 2009. PMID: 19176804 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Molecular Biology Databases

  • FlyBase