Course and prognosis of Crohn's disease - PubMed (original) (raw)
Course and prognosis of Crohn's disease
S C Truelove et al. Gut. 1976 Mar.
Abstract
During the period 1938-70 there were 303 patients at the Radcliffe Infirmary, Oxford, diagnosed as suffering from Crohn's disease. Of these, 82 have been excluded, leaving 221 with a firm diagnosis. These patients have been divided into 'new cases', in which the disease was diagnosed at the Radcliffe Infirmary, and 'referred cases' in which the diagnosis was already made at the time of referral. In this series, there were three main sites of involvement: small intestinal, large intestinal, and both small and large intestinal. Ileocolitis was the commonest anatomical distribution. The disease showed progression to new, sites in a considerable number of the patients during the period under study. There was a fivefold increase of new cases between the first and third decades covered by the study and this applied equally to patients presenting as an acute abdomen, which supports the idea that the disease is truly increasing. Survival curves have been plotted and compared with expected survival curves. In terms of mortality, Crohn's disease emerges as a disease which becomes progressively more dangerous as the years go by, which is in sharp contrast with the findings in ulcerative colitis in which the main risk of dying is in the early years.
Similar articles
- The prognosis of inflammatory bowel disease.
Sales DJ, Kirsner JB. Sales DJ, et al. Arch Intern Med. 1983 Feb;143(2):294-9. Arch Intern Med. 1983. PMID: 6824395 - [Incidence of inflammatory bowel diseases in Bretagne (1994-1995). ABERMAD. Association Bertonne d'Etude et de Recherche des Maladies de l'Appareil Digesif].
Pagenault M, Tron I, Alexandre JL, Cruchant E, Dabadie A, Chaperon J, Robaszkiewicz M, Bretagne JF. Pagenault M, et al. Gastroenterol Clin Biol. 1997;21(6-7):483-90. Gastroenterol Clin Biol. 1997. PMID: 9295976 French. - Increased risk of colorectal cancer and dysplasia in patients with Crohn's colitis and primary sclerosing cholangitis.
Lindström L, Lapidus A, Ost A, Bergquist A. Lindström L, et al. Dis Colon Rectum. 2011 Nov;54(11):1392-7. doi: 10.1097/DCR.0b013e31822bbcc1. Dis Colon Rectum. 2011. PMID: 21979184 - Mortality in Crohn's disease.
Prior P, Gyde S, Cooke WT, Waterhouse JA, Allan RN. Prior P, et al. Gastroenterology. 1981 Feb;80(2):307-12. Gastroenterology. 1981. PMID: 7450421 - Free perforation in Crohn's disease: I. A survey of 99 cases.
Greenstein AJ, Mann D, Sachar DB, Aufses AH Jr. Greenstein AJ, et al. Am J Gastroenterol. 1985 Sep;80(9):682-9. Am J Gastroenterol. 1985. PMID: 3898819 Review.
Cited by
- Preoperative Ustekinumab Treatment Is Not Associated With Increased Postoperative Complications in Crohn's Disease: A Canadian Multi-Centre Observational Cohort Study.
Shim HH, Ma C, Kotze PG, Seow CH, Al-Farhan H, Al-Darmaki AK, Pang JXQ, Fedorak RN, Devlin SM, Dieleman LA, Kaplan GG, Novak KL, Kroeker KI, Halloran BP, Panaccione R. Shim HH, et al. J Can Assoc Gastroenterol. 2018 Sep;1(3):115-123. doi: 10.1093/jcag/gwy013. Epub 2018 May 10. J Can Assoc Gastroenterol. 2018. PMID: 31294352 Free PMC article. - Serum Cytokine Profiles in Children with Crohn's Disease.
Vasilyeva E, Abdulkhakov S, Cherepnev G, Martynova E, Mayanskaya I, Valeeva A, Abdulkhakov R, Safina D, Khaiboullina S, Rizvanov A. Vasilyeva E, et al. Mediators Inflamm. 2016;2016:7420127. doi: 10.1155/2016/7420127. Epub 2016 Dec 13. Mediators Inflamm. 2016. PMID: 28070144 Free PMC article. - Trends in the Surgical Management of Crohn's Disease.
Geltzeiler CB, Hart KD, Lu KC, Deveney KE, Herzig DO, Tsikitis VL. Geltzeiler CB, et al. J Gastrointest Surg. 2015 Oct;19(10):1862-8. doi: 10.1007/s11605-015-2911-3. Epub 2015 Aug 19. J Gastrointest Surg. 2015. PMID: 26286366 - CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Huang YH, et al. Nature. 2015 Jan 15;517(7534):386-90. doi: 10.1038/nature13848. Epub 2014 Oct 26. Nature. 2015. PMID: 25363763 Free PMC article. - Coagulation parameters in inflammatory bowel disease.
Dolapcioglu C, Soylu A, Kendir T, Ince AT, Dolapcioglu H, Purisa S, Bolukbas C, Sokmen HM, Dalay R, Ovunc O. Dolapcioglu C, et al. Int J Clin Exp Med. 2014 May 15;7(5):1442-8. eCollection 2014. Int J Clin Exp Med. 2014. PMID: 24995109 Free PMC article.
References
- Lancet. 1974 Sep 21;2(7882):691-3 - PubMed
- N Engl J Med. 1973 Nov 22;289(21):1099-103 - PubMed
- Q J Med. 1971 Apr;40(158):187-209 - PubMed
- Scand J Gastroenterol. 1971;6(1):97-108 - PubMed
- Scand J Gastroenterol. 1970;5(5):385-90 - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources