Triggering the interferon antiviral response through an IKK-related pathway - PubMed (original) (raw)

. 2003 May 16;300(5622):1148-51.

doi: 10.1126/science.1081315. Epub 2003 Apr 17.

Affiliations

• PMID: 12702806
• DOI: 10.1126/science.1081315

Triggering the interferon antiviral response through an IKK-related pathway

Sonia Sharma et al. Science. 2003.

Abstract

Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.

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Comment in

• Immunology. A viral on/off switch for interferon.
  Williams BR, Sen GC. Williams BR, et al. Science. 2003 May 16;300(5622):1100-1. doi: 10.1126/science.1085277. Science. 2003. PMID: 12750505 No abstract available.
• Protease inhibitors for treatment of chronic hepatitis C--a new target for the magic bullet identified.
  Ferenci P. Ferenci P. J Hepatol. 2004 Jan;40(1):184-6. doi: 10.1016/j.jhep.2003.10.015. J Hepatol. 2004. PMID: 14672633 No abstract available.

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