Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? - PubMed (original) (raw)

Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?

G Chételat et al. Neurology. 2003.

Abstract

Patients with mild cognitive impairment (MCI) were assessed, and a metabolic profile associated with conversion to AD at 18-month follow-up was sought. As compared with nonconverters (n = 10), converters (n = 7) had lower fluorodeoxyglucose uptake in the right temporoparietal cortex (p = 0.02, corrected for cluster size), without individual overlap. Awaiting replication in an independent sample, these findings suggest that among patients with MCI, fluorodeoxyglucose PET may accurately identify rapid converters.

PubMed Disclaimer

Similar articles

• Decreased cortical glucose metabolism in converters from CDR 0.5 to Alzheimer's disease in a community: the Osaki-Tajiri Project.
  Ishii H, Ishikawa H, Meguro K, Tashiro M, Yamaguchi S. Ishii H, et al. Int Psychogeriatr. 2009 Feb;21(1):148-56. doi: 10.1017/S1041610208008132. Epub 2008 Dec 1. Int Psychogeriatr. 2009. PMID: 19040787
• MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.
  Mosconi L, Perani D, Sorbi S, Herholz K, Nacmias B, Holthoff V, Salmon E, Baron JC, De Cristofaro MT, Padovani A, Borroni B, Franceschi M, Bracco L, Pupi A. Mosconi L, et al. Neurology. 2004 Dec 28;63(12):2332-40. doi: 10.1212/01.wnl.0000147469.18313.3b. Neurology. 2004. PMID: 15623696
• Cerebral metabolic correlates of the clinical dementia rating scale in mild cognitive impairment.
  Perneczky R, Hartmann J, Grimmer T, Drzezga A, Kurz A. Perneczky R, et al. J Geriatr Psychiatry Neurol. 2007 Jun;20(2):84-8. doi: 10.1177/0891988706297093. J Geriatr Psychiatry Neurol. 2007. PMID: 17548777
• Impaired cerebral glucose metabolism in prodromal Alzheimer's disease differs by regional intensity normalization.
  Küntzelmann A, Guenther T, Haberkorn U, Essig M, Giesel F, Henze R, Schroeter ML, Schröder J, Schönknecht P. Küntzelmann A, et al. Neurosci Lett. 2013 Feb 8;534:12-7. doi: 10.1016/j.neulet.2012.11.026. Epub 2012 Nov 23. Neurosci Lett. 2013. PMID: 23182881
• Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.
  Mosconi L. Mosconi L. Eur J Nucl Med Mol Imaging. 2005 Apr;32(4):486-510. doi: 10.1007/s00259-005-1762-7. Eur J Nucl Med Mol Imaging. 2005. PMID: 15747152 Review.

Cited by

• Relationship between baseline brain metabolism measured using [¹⁸F]FDG PET and memory and executive function in prodromal and early Alzheimer's disease.
  Habeck C, Risacher S, Lee GJ, Glymour MM, Mormino E, Mukherjee S, Kim S, Nho K, DeCarli C, Saykin AJ, Crane PK; Alzheimer’s Disease Neuroimaging Initiative. Habeck C, et al. Brain Imaging Behav. 2012 Dec;6(4):568-83. doi: 10.1007/s11682-012-9208-x. Brain Imaging Behav. 2012. PMID: 23179062 Free PMC article.
• ¹⁸F-FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
  Smailagic N, Vacante M, Hyde C, Martin S, Ukoumunne O, Sachpekidis C. Smailagic N, et al. Cochrane Database Syst Rev. 2015 Jan 28;1(1):CD010632. doi: 10.1002/14651858.CD010632.pub2. Cochrane Database Syst Rev. 2015. PMID: 25629415 Free PMC article. Review.
• Brain imaging in Alzheimer disease.
  Johnson KA, Fox NC, Sperling RA, Klunk WE. Johnson KA, et al. Cold Spring Harb Perspect Med. 2012 Apr;2(4):a006213. doi: 10.1101/cshperspect.a006213. Cold Spring Harb Perspect Med. 2012. PMID: 22474610 Free PMC article. Review.
• 18F-FDG PET for Prediction of Conversion to Alzheimer's Disease Dementia in People with Mild Cognitive Impairment: An Updated Systematic Review of Test Accuracy.
  Smailagic N, Lafortune L, Kelly S, Hyde C, Brayne C. Smailagic N, et al. J Alzheimers Dis. 2018;64(4):1175-1194. doi: 10.3233/JAD-171125. J Alzheimers Dis. 2018. PMID: 30010119 Free PMC article.
• Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.
  Kantarci K, Weigand SD, Petersen RC, Boeve BF, Knopman DS, Gunter J, Reyes D, Shiung M, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Jack CR Jr. Kantarci K, et al. Neurobiol Aging. 2007 Sep;28(9):1330-9. doi: 10.1016/j.neurobiolaging.2006.06.018. Epub 2006 Jul 24. Neurobiol Aging. 2007. PMID: 16860440 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program