How introns influence and enhance eukaryotic gene expression - PubMed (original) (raw)
Review
How introns influence and enhance eukaryotic gene expression
Hervé Le Hir et al. Trends Biochem Sci. 2003 Apr.
Abstract
Although it has been known since the late 1970s that intron-containing and intronless versions of otherwise identical genes can exhibit dramatically different expression profiles, the underlying molecular mechanisms have only lately come to light. This review summarizes recent progress in our understanding of how introns and the act of their removal by the spliceosome can influence and enhance almost every step of mRNA metabolism. A rudimentary understanding of these effects can prove invaluable to researchers interested in optimizing transgene expression in eukaryotic systems.
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