Missing genes in metabolic pathways: a comparative genomics approach - PubMed (original) (raw)
Review
Missing genes in metabolic pathways: a comparative genomics approach
Andrei Osterman et al. Curr Opin Chem Biol. 2003 Apr.
Abstract
The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.
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