Chronic graft-versus-host disease - PubMed (original) (raw)

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Chronic graft-versus-host disease

Stephanie J Lee et al. Biol Blood Marrow Transplant. 2003 Apr.

Free article

Abstract

Chronic graft-versus-host disease (GVHD) remains a vexing and dangerous complication of allogeneic stem cell transplantation. Mild forms of chronic GVHD are often manageable with local or low-dose systemic immunosuppression and do not affect long-term survival. In contrast, more severe forms of chronic GVHD require intensive medical management and adversely affect survival. This report reviews current concepts of the pathogenesis, clinical risk factors, classification systems, organ manifestations, and available treatments for chronic GVHD. It also provides a comprehensive listing of the published clinical trials aimed at prevention and primary treatment of chronic GVHD.

Copyright 2003 American Society for Blood and Marrow Transplantation

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Comment in

• Re: chronic graft-versus-host disease.
  Flowers ME, Lee S, Vogelsang G. Flowers ME, et al. Biol Blood Marrow Transplant. 2003 Aug;9(8):540. doi: 10.1016/s1083-8791(03)00231-3. Biol Blood Marrow Transplant. 2003. PMID: 12931123 No abstract available.

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