Contextual inhibitory gating of impulse traffic in the intra-amygdaloid network - PubMed (original) (raw)
Review
Contextual inhibitory gating of impulse traffic in the intra-amygdaloid network
Denis Paré et al. Ann N Y Acad Sci. 2003 Apr.
Abstract
New data on the organization of the intra-amygdaloid circuit is reviewed, beginning with the basolateral (BL) complex, the main input station of the amygdala for sensory afferents, and concluding with the central (CE) nucleus, an important source of projections to brain-stem structures mediating fear responses. The BL complex is endowed with a highly divergent system of intrinsic glutamatergic connections. Yet, BL projection cells have unusually low firing rates. This apparent contradiction is explained by the presence of powerful inhibitory pressures in the BL amygdala: (1) interneurons that generate large-amplitude inhibitory synaptic potentials and (2) projection cells that express a Ca(2+)-dependent K(+) current that can be activated by subthreshold synaptic inputs. Likewise, excitatory projections from the BL amygdala to the CE nucleus are controlled by clusters of GABAergic neurons, termed the intercalated (ITC) cell masses. In response to BL inputs, ITC cells generate feedforward inhibition in CE neurons. However, ITC neurons exhibit properties that allow them to modify the amount of inhibition they generate depending on the distribution of BL activity in space and time. Indeed, ITC cell masses can inhibit each other via lateromedial connections. Moreover, they express an unusual K(+) conductance that modifies their response to BL inputs depending on their recent firing history. Thus, inhibitory mechanisms of the amygdala allow for flexible, context-dependent gating of BL impulses to the CE nucleus.
Similar articles
- Polarized synaptic interactions between intercalated neurons of the amygdala.
Royer S, Martina M, Paré D. Royer S, et al. J Neurophysiol. 2000 Jun;83(6):3509-18. doi: 10.1152/jn.2000.83.6.3509. J Neurophysiol. 2000. PMID: 10848566 - An inhibitory interface gates impulse traffic between the input and output stations of the amygdala.
Royer S, Martina M, Paré D. Royer S, et al. J Neurosci. 1999 Dec 1;19(23):10575-83. doi: 10.1523/JNEUROSCI.19-23-10575.1999. J Neurosci. 1999. PMID: 10575053 Free PMC article. - Bistable behavior of inhibitory neurons controlling impulse traffic through the amygdala: role of a slowly deinactivating K+ current.
Royer S, Martina M, Pare D. Royer S, et al. J Neurosci. 2000 Dec 15;20(24):9034-9. doi: 10.1523/JNEUROSCI.20-24-09034.2000. J Neurosci. 2000. PMID: 11124979 Free PMC article. - The intrinsic organization of the central extended amygdala.
Cassell MD, Freedman LJ, Shi C. Cassell MD, et al. Ann N Y Acad Sci. 1999 Jun 29;877:217-41. doi: 10.1111/j.1749-6632.1999.tb09270.x. Ann N Y Acad Sci. 1999. PMID: 10415652 Review. - Interneurons in the basolateral amygdala.
Spampanato J, Polepalli J, Sah P. Spampanato J, et al. Neuropharmacology. 2011 Apr;60(5):765-73. doi: 10.1016/j.neuropharm.2010.11.006. Epub 2010 Nov 18. Neuropharmacology. 2011. PMID: 21093462 Review.
Cited by
- Central amygdala CRF+ neurons promote heightened threat reactivity following early life adversity in mice.
Demaestri C, Pisciotta M, Altunkeser N, Berry G, Hyland H, Breton J, Darling A, Williams B, Bath KG. Demaestri C, et al. Nat Commun. 2024 Jun 29;15(1):5522. doi: 10.1038/s41467-024-49828-3. Nat Commun. 2024. PMID: 38951506 Free PMC article. - Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesis.
Yang YC, Wang GH, Chou P, Hsueh SW, Lai YC, Kuo CC. Yang YC, et al. Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2313042121. doi: 10.1073/pnas.2313042121. Epub 2024 Feb 12. Proc Natl Acad Sci U S A. 2024. PMID: 38346194 Free PMC article. - The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning.
Sepahvand T, Power KD, Qin T, Yuan Q. Sepahvand T, et al. Biology (Basel). 2023 Sep 22;12(10):1274. doi: 10.3390/biology12101274. Biology (Basel). 2023. PMID: 37886984 Free PMC article. Review. - Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression.
Sepahvand T, Nazari N, Qin T, Rajani V, Yuan Q. Sepahvand T, et al. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2309986120. doi: 10.1073/pnas.2309986120. Epub 2023 Oct 25. Proc Natl Acad Sci U S A. 2023. PMID: 37878718 Free PMC article. - Dopaminergic circuits underlying associative aversive learning.
Zafiri D, Duvarci S. Zafiri D, et al. Front Behav Neurosci. 2022 Nov 10;16:1041929. doi: 10.3389/fnbeh.2022.1041929. eCollection 2022. Front Behav Neurosci. 2022. PMID: 36439963 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous