TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes - PubMed (original) (raw)

. 2003 Jul 18;278(29):26629-38.

doi: 10.1074/jbc.M304044200. Epub 2003 May 6.

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• PMID: 12736256
• DOI: 10.1074/jbc.M304044200

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TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes

Stephan Philipp et al. J Biol Chem. 2003.

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Abstract

Stimulation of the T-cell receptor (TCR) activates Ca2+ entry across the plasma membrane, which is a key triggering event for the T-cell-associated immune response. We show that TRPC3 channels are important for the TCR-dependent Ca2+ entry pathway. The TRPC3 gene was found to be damaged in human T-cell mutants defective in Ca2+ influx. Mutations of the TRPC3 gene were accompanied by changes of TRPC3 gene expression. Introduction of the complete human TRPC3 cDNA into those mutants rescued Ca2+ currents as well as TCR-dependent Ca2+ signals. Our data provide the initial step toward understanding the molecular nature of endogenous Ca2+ channels participating in T-cell activation and put forward TRPC3 as a new target for modulating the immune response.

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