Selective degradation of peroxisomes in yeasts - PubMed (original) (raw)

Review

. 2003 Jun 1;61(2):161-70.

doi: 10.1002/jemt.10325.

Affiliations

• PMID: 12740822
• DOI: 10.1002/jemt.10325

Review

Selective degradation of peroxisomes in yeasts

Anna Rita Bellu et al. Microsc Res Tech. 2003.

Abstract

In the last two decades, much progress has been made in understanding the process of induction and biogenesis of peroxisomes, essential organelles in all eukaryotes. Only relatively recently, the first molecular studies on the selective degradation of this important organelle-a process known as pexophagy, which occurs when the organelles have become redundant-have been performed, especially using methylotrophic yeasts. The finding that pexophagy and other transport pathways to the vacuole (vacuolar protein sorting, autophagy, cytoplasm-to-vacuole-targeting and endocytosis) utilize common but also unique genes has placed pexophagy in the heart of the machinery that recycles cellular material. The quest is now on to understand how peroxisome degradation has become such a highly selective process and what the signals are that trigger it. In addition, because the prime determinant of pexophagy is located on the peroxisome itself, it has become essential to study the role of peroxisomal membrane proteins in the degradation process in detail. This review highlights the main achievements of the last years.

Copyright 2003 Wiley-Liss, Inc.

PubMed Disclaimer

Similar articles

• [Molecular mechanisms of autophagic peroxisome degradation in yeasts].
  Nazarko TIu, Sybirnyĭ AA. Nazarko TIu, et al. Ukr Biokhim Zh (1999). 2005 Mar-Apr;77(2):16-25. Ukr Biokhim Zh (1999). 2005. PMID: 16335232 Review. Ukrainian.
• Peroxisome homeostasis in Hansenula polymorpha.
  Leão AN, Kiel JA. Leão AN, et al. FEMS Yeast Res. 2003 Nov;4(2):131-9. doi: 10.1016/S1567-1356(03)00070-9. FEMS Yeast Res. 2003. PMID: 14613877 Review.
• Pexophagy-linked degradation of the peroxisomal membrane protein Pex3p involves the ubiquitin-proteasome system.
  Williams C, van der Klei IJ. Williams C, et al. Biochem Biophys Res Commun. 2013 Aug 23;438(2):395-401. doi: 10.1016/j.bbrc.2013.07.086. Epub 2013 Jul 27. Biochem Biophys Res Commun. 2013. PMID: 23899522
• Peroxisome turnover by micropexophagy: an autophagy-related process.
  Farré JC, Subramani S. Farré JC, et al. Trends Cell Biol. 2004 Sep;14(9):515-23. doi: 10.1016/j.tcb.2004.07.014. Trends Cell Biol. 2004. PMID: 15350980 Review.
• Mechanisms of autophagy and pexophagy in yeasts.
  Sibirny AA. Sibirny AA. Biochemistry (Mosc). 2011 Dec;76(12):1279-90. doi: 10.1134/S0006297911120017. Biochemistry (Mosc). 2011. PMID: 22150273 Review.

Cited by

• ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.
  Brennand A, Rico E, Rigden DJ, Van Der Smissen P, Courtoy PJ, Michels PA. Brennand A, et al. PLoS One. 2015 Jun 19;10(6):e0130365. doi: 10.1371/journal.pone.0130365. eCollection 2015. PLoS One. 2015. PMID: 26090847 Free PMC article.
• Molecular mechanism and physiological role of pexophagy.
  Manjithaya R, Nazarko TY, Farré JC, Subramani S. Manjithaya R, et al. FEBS Lett. 2010 Apr 2;584(7):1367-73. doi: 10.1016/j.febslet.2010.01.019. Epub 2010 Jan 17. FEBS Lett. 2010. PMID: 20083110 Free PMC article. Review.
• Autophagy and neurodegeneration.
  Ventruti A, Cuervo AM. Ventruti A, et al. Curr Neurol Neurosci Rep. 2007 Sep;7(5):443-51. doi: 10.1007/s11910-007-0068-5. Curr Neurol Neurosci Rep. 2007. PMID: 17764636 Review.
• Lumenal peroxisomal protein aggregates are removed by concerted fission and autophagy events.
  Manivannan S, de Boer R, Veenhuis M, van der Klei IJ. Manivannan S, et al. Autophagy. 2013 Jul;9(7):1044-56. doi: 10.4161/auto.24543. Epub 2013 Apr 9. Autophagy. 2013. PMID: 23614977 Free PMC article.
• Evolution of energy metabolism and its compartmentation in Kinetoplastida.
  Hannaert V, Bringaud F, Opperdoes FR, Michels PA. Hannaert V, et al. Kinetoplastid Biol Dis. 2003 Oct 28;2(1):11. doi: 10.1186/1475-9292-2-11. Kinetoplastid Biol Dis. 2003. PMID: 14613499 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley