Shunting inhibition modulates neuronal gain during synaptic excitation - PubMed (original) (raw)
Shunting inhibition modulates neuronal gain during synaptic excitation
Simon J Mitchell et al. Neuron. 2003.
Free article
Abstract
Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar granule cell input-output relationships during frequency-dependent excitation with synaptic conductance waveforms. Shunting inhibition scales subthreshold voltage, increasing the excitation frequency required to attain a particular firing rate. This reduces gain because frequency-dependent increases in input variability, which couple mean subthreshold voltage to firing rate, boost voltage fluctuations during inhibition. Moreover, synaptic time course and the number of inputs also influence gain changes by setting excitation variability. Our results suggest that shunting inhibition can multiplicatively scale rate-coded information in neurons with high-variability synaptic inputs.
Similar articles
- Gain control by concerted changes in I(A) and I(H) conductances.
Burdakov D. Burdakov D. Neural Comput. 2005 May;17(5):991-995. doi: 10.1162/0899766053491841. Neural Comput. 2005. PMID: 15881793 Free PMC article. - Neuronal integration of synaptic input in the fluctuation-driven regime.
Kuhn A, Aertsen A, Rotter S. Kuhn A, et al. J Neurosci. 2004 Mar 10;24(10):2345-56. doi: 10.1523/JNEUROSCI.3349-03.2004. J Neurosci. 2004. PMID: 15014109 Free PMC article. - Gain modulation from background synaptic input.
Chance FS, Abbott LF, Reyes AD. Chance FS, et al. Neuron. 2002 Aug 15;35(4):773-82. doi: 10.1016/s0896-6273(02)00820-6. Neuron. 2002. PMID: 12194875 - A new mechanism for neuronal gain control (or how the gain in brains has mainly been explained).
Priebe NJ, Ferster D. Priebe NJ, et al. Neuron. 2002 Aug 15;35(4):602-4. doi: 10.1016/s0896-6273(02)00829-2. Neuron. 2002. PMID: 12194862 Review. - Drivers and modulators from push-pull and balanced synaptic input.
Abbott LF, Chance FS. Abbott LF, et al. Prog Brain Res. 2005;149:147-55. doi: 10.1016/S0079-6123(05)49011-1. Prog Brain Res. 2005. PMID: 16226582 Review.
Cited by
- Dynamic excitatory and inhibitory gain modulation can produce flexible, robust and optimal decision-making.
Niyogi RK, Wong-Lin K. Niyogi RK, et al. PLoS Comput Biol. 2013;9(6):e1003099. doi: 10.1371/journal.pcbi.1003099. Epub 2013 Jun 27. PLoS Comput Biol. 2013. PMID: 23825935 Free PMC article. - Recognition Memory Induces Natural LTP-like Hippocampal Synaptic Excitation and Inhibition.
Sánchez-Rodríguez I, Temprano-Carazo S, Jeremic D, Delgado-Garcia JM, Gruart A, Navarro-López JD, Jiménez-Díaz L. Sánchez-Rodríguez I, et al. Int J Mol Sci. 2022 Sep 16;23(18):10806. doi: 10.3390/ijms231810806. Int J Mol Sci. 2022. PMID: 36142727 Free PMC article. - Non-linear Membrane Properties in Entorhinal Cortical Stellate Cells Reduce Modulation of Input-Output Responses by Voltage Fluctuations.
Fernandez FR, Malerba P, White JA. Fernandez FR, et al. PLoS Comput Biol. 2015 Apr 24;11(4):e1004188. doi: 10.1371/journal.pcbi.1004188. eCollection 2015 Apr. PLoS Comput Biol. 2015. PMID: 25909971 Free PMC article. - Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum.
Brill-Weil SG, Kramer PF, Yanez A, Clever FH, Zhang R, Khaliq ZM. Brill-Weil SG, et al. bioRxiv [Preprint]. 2024 Jun 25:2024.06.25.600616. doi: 10.1101/2024.06.25.600616. bioRxiv. 2024. PMID: 39372741 Free PMC article. Preprint. - Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.
Yu J, Proddutur A, Elgammal FS, Ito T, Santhakumar V. Yu J, et al. J Neurophysiol. 2013 Apr;109(7):1746-63. doi: 10.1152/jn.00891.2012. Epub 2013 Jan 16. J Neurophysiol. 2013. PMID: 23324316 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources