Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability - PubMed (original) (raw)
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
Vivien Chevaleyre et al. Neuron. 2003.
Free article
Erratum in
- Neuron. 2003 Jun 19;38(6):997
Abstract
Neuronal excitability and long-term synaptic plasticity at excitatory synapses are critically dependent on the level of inhibition, and accordingly, changes of inhibitory synaptic efficacy should have great impact on neuronal function and neural network processing. We describe here a form of activity-dependent long-term depression at hippocampal inhibitory synapses that is triggered postsynaptically via glutamate receptor activation but is expressed presynaptically. That is, glutamate released by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids. This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory.
Comment in
- Excitement reduces inhibition via endocannabinoids.
Freund TF, Hájos N. Freund TF, et al. Neuron. 2003 May 8;38(3):362-5. doi: 10.1016/s0896-6273(03)00262-9. Neuron. 2003. PMID: 12741983 Review.
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