Pre-ribosomes on the road from the nucleolus to the cytoplasm - PubMed (original) (raw)

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Pre-ribosomes on the road from the nucleolus to the cytoplasm

Herbert Tschochner et al. Trends Cell Biol. 2003 May.

Abstract

Eukaryotic ribosomes are assembled in the nucleolus before export to the cytoplasm. Ribosome formation is a highly dynamic and coordinated multistep process, which requires synthesis, processing and modification of pre-rRNAs, assembly with ribosomal proteins and transient interaction of numerous non-ribosomal factors with the evolving pre-ribosomal particles. In the past two years, exciting insights into the sequential events occurring during pre-ribosome formation have been obtained, thanks largely to the advances in proteomic analyses. We now have a first biochemical map of the earliest 90S pre-ribosomes and of their daughter pre-40S and pre-60S ribosomal subunits along their path from the nucleolus to the cytoplasm. The future challenge will be to assign functions to the more than 150 non-ribosomal factors that transiently associate with the developing pre-ribosomes.

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Pre-ribosomes on the road from the nucleolus to the cytoplasm - PubMed (original) (raw)