Telomere repeat binding factors: keeping the ends in check - PubMed (original) (raw)
Review
Telomere repeat binding factors: keeping the ends in check
Jan Karlseder. Cancer Lett. 2003.
Abstract
Per definition, a linear chromosome contains two ends, two sites, which by analogy to double-stranded breaks, might be expected to induce cell cycle checkpoints. The fact that cells divide without inducing such checkpoints suggests that telomeres, the natural ends of linear chromosomes, have the ability to suppress checkpoint activation. This suppression takes place at a number of levels. The TTAGGG repeats of human telomeric DNA recruit telomere specific proteins, among them the telomere repeat binding factors TRF1 and TRF2. These proteins, along with their interaction partners, reorganize the linear chromosome end into a t loop, a protected structure, which hides the very end of the chromosome. Here it is discussed how mammalian telomeres differ from DNA breaks, and what methods they use to prevent checkpoint activation.
Similar articles
- The Connection Between Cell Fate and Telomere.
Engin AB, Engin A. Engin AB, et al. Adv Exp Med Biol. 2021;1275:71-100. doi: 10.1007/978-3-030-49844-3_3. Adv Exp Med Biol. 2021. PMID: 33539012 Review. - Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas.
Matsutani N, Yokozaki H, Tahara E, Tahara H, Kuniyasu H, Haruma K, Chayama K, Yasui W, Tahara E. Matsutani N, et al. Int J Oncol. 2001 Sep;19(3):507-12. Int J Oncol. 2001. PMID: 11494028 - Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
Broccoli D, Smogorzewska A, Chong L, de Lange T. Broccoli D, et al. Nat Genet. 1997 Oct;17(2):231-5. doi: 10.1038/ng1097-231. Nat Genet. 1997. PMID: 9326950 - [Recognition of internal (TTAGGG)n repeats by telomeric protein TRF1 and its role in maintenance of chromosomal stability in Chinese hamster cells].
Krutilina RI, Smirnova AN, Mudrak OS, Svetlova MP, Pleskach NM, Oei SL, Bradbury EM, Zalensky AO, Tomilin NV. Krutilina RI, et al. Tsitologiia. 2003;45(12):1211-20. Tsitologiia. 2003. PMID: 15027354 Russian.
Cited by
- Telomere length and risk of developing gastric adenocarcinoma: The Singapore Chinese Health Study.
Wang Z, Koh WP, Jin A, Wang R, Yuan JM. Wang Z, et al. Gastric Cancer. 2018 Jul;21(4):598-605. doi: 10.1007/s10120-017-0783-9. Epub 2017 Dec 7. Gastric Cancer. 2018. PMID: 29218426 Free PMC article. - Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.
Bellon M, Nicot C. Bellon M, et al. Int J Cancer Oncol. 2015 Jun 2;2(2):215. doi: 10.15436/2377-0902.15.017. Int J Cancer Oncol. 2015. PMID: 26430700 Free PMC article. - Heregulin, a new regulator of telomere length in human cells.
Menendez JA, Rubio MA, Campisi J, Lupu R. Menendez JA, et al. Oncotarget. 2015 Nov 24;6(37):39422-36. doi: 10.18632/oncotarget.4964. Oncotarget. 2015. PMID: 26318724 Free PMC article. - A beginning of the end: new insights into the functional organization of telomeres.
Wood AM, Laster K, Rice EL, Kosak ST. Wood AM, et al. Nucleus. 2015;6(3):172-8. doi: 10.1080/19491034.2015.1048407. Nucleus. 2015. PMID: 25961132 Free PMC article. - Multiple facets of TPP1 in telomere maintenance.
Rajavel M, Mullins MR, Taylor DJ. Rajavel M, et al. Biochim Biophys Acta. 2014 Sep;1844(9):1550-9. doi: 10.1016/j.bbapap.2014.04.014. Epub 2014 Apr 26. Biochim Biophys Acta. 2014. PMID: 24780581 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous