The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases - PubMed (original) (raw)
Review
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases
Manfred Thiel et al. Microbes Infect. 2003 May.
Free article
Abstract
Adenosine can be described as a retaliatory metabolite, the production and release of which is usually enhanced under adverse environmental conditions. Binding via specific receptors, adenosine activates endogenous protective mechanisms aiming at the restoration of tissue homeostasis. While adenosinergic downregulation of tissue damage is beneficial in acute inflammation, chronic suppression of the immune system by adenosine may account for immunoparalysis in long-term septic patients.
Similar articles
- Modulation of innate immunity by adenosine receptor stimulation.
Ramakers BP, Riksen NP, van der Hoeven JG, Smits P, Pickkers P. Ramakers BP, et al. Shock. 2011 Sep;36(3):208-15. doi: 10.1097/SHK.0b013e318225aee4. Shock. 2011. PMID: 21617576 Review. - Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases.
Cronstein BN, Sitkovsky M. Cronstein BN, et al. Nat Rev Rheumatol. 2017 Jan;13(1):41-51. doi: 10.1038/nrrheum.2016.178. Epub 2016 Nov 10. Nat Rev Rheumatol. 2017. PMID: 27829671 Free PMC article. Review. - Adenosine signaling and the immune system: When a lot could be too much.
Antonioli L, Fornai M, Blandizzi C, Pacher P, Haskó G. Antonioli L, et al. Immunol Lett. 2019 Jan;205:9-15. doi: 10.1016/j.imlet.2018.04.006. Epub 2018 Apr 24. Immunol Lett. 2019. PMID: 29702147 Review. - Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes.
Link AA, Kino T, Worth JA, McGuire JL, Crane ML, Chrousos GP, Wilder RL, Elenkov IJ. Link AA, et al. J Immunol. 2000 Jan 1;164(1):436-42. doi: 10.4049/jimmunol.164.1.436. J Immunol. 2000. PMID: 10605040 - Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo.
Gomez G, Sitkovsky MV. Gomez G, et al. Int J Biochem Cell Biol. 2003 Apr;35(4):410-4. doi: 10.1016/s1357-2725(02)00177-2. Int J Biochem Cell Biol. 2003. PMID: 12565702 Review.
Cited by
- Purinergic signaling during Porphyromonas gingivalis infection.
Almeida-da-Silva CLC, Morandini AC, Ulrich H, Ojcius DM, Coutinho-Silva R. Almeida-da-Silva CLC, et al. Biomed J. 2016 Aug;39(4):251-260. doi: 10.1016/j.bj.2016.08.003. Epub 2016 Sep 24. Biomed J. 2016. PMID: 27793267 Free PMC article. Review. - Activation of adenosine A2A receptors inhibits neutrophil transuroepithelial migration.
Säve S, Mohlin C, Vumma R, Persson K. Säve S, et al. Infect Immun. 2011 Aug;79(8):3431-7. doi: 10.1128/IAI.05005-11. Epub 2011 Jun 6. Infect Immun. 2011. PMID: 21646447 Free PMC article. - Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells.
Sitkovsky M, Lukashev D, Deaglio S, Dwyer K, Robson SC, Ohta A. Sitkovsky M, et al. Br J Pharmacol. 2008 Mar;153 Suppl 1(Suppl 1):S457-64. doi: 10.1038/bjp.2008.23. Br J Pharmacol. 2008. PMID: 18311159 Free PMC article. Review. - The interplay between metabolic remodeling and immune regulation in glioblastoma.
Kesarwani P, Kant S, Prabhu A, Chinnaiyan P. Kesarwani P, et al. Neuro Oncol. 2017 Oct 1;19(10):1308-1315. doi: 10.1093/neuonc/nox079. Neuro Oncol. 2017. PMID: 28541512 Free PMC article. Review. - Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils.
McColl SR, St-Onge M, Dussault AA, Laflamme C, Bouchard L, Boulanger J, Pouliot M. McColl SR, et al. FASEB J. 2006 Jan;20(1):187-9. doi: 10.1096/fj.05-4804fje. Epub 2005 Nov 9. FASEB J. 2006. PMID: 16280366 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical