The TRPC3/6/7 subfamily of cation channels - PubMed (original) (raw)
Review
The TRPC3/6/7 subfamily of cation channels
Mohamed Trebak et al. Cell Calcium. 2003 May-Jun.
Abstract
The mammalian transient receptor potential (TRP) proteins consist of a superfamily of Ca2+-permeant non-selective cation channels with structural similarities to Drosophila TRP. The TRP superfamily can be divided into three major families, among them the "canonical TRP" family (TRPC). The seven protein products of the mammalian TRPC family of genes (designated TRPC1-7) share in common the activation through PLC-coupled receptors and have been proposed to encode components of native store-operated channels in different cell types. In addition, the three members of the TRPC3/6/7 subfamily of TRPC channels can be activated by diacylglycerol analogs, providing a possible mechanism of activation of these channels by PLC-coupled receptors. This review summarizes the current knowledge about the mechanism of activation of the TRPC3/6/7 subfamily, as well as the potential role of these proteins as components of native Ca2+-permeant channels.
Similar articles
- Transient receptor potential channels in endothelium: solving the calcium entry puzzle?
Nilius B, Droogmans G, Wondergem R. Nilius B, et al. Endothelium. 2003;10(1):5-15. doi: 10.1080/10623320303356. Endothelium. 2003. PMID: 12699072 Review. - Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells.
Zagranichnaya TK, Wu X, Villereal ML. Zagranichnaya TK, et al. J Biol Chem. 2005 Aug 19;280(33):29559-69. doi: 10.1074/jbc.M505842200. Epub 2005 Jun 22. J Biol Chem. 2005. PMID: 15972814 - A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.
He LP, Hewavitharana T, Soboloff J, Spassova MA, Gill DL. He LP, et al. J Biol Chem. 2005 Mar 25;280(12):10997-1006. doi: 10.1074/jbc.M411797200. Epub 2005 Jan 12. J Biol Chem. 2005. PMID: 15647288 - Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells.
Lièvremont JP, Bird GS, Putney JW Jr. Lièvremont JP, et al. Am J Physiol Cell Physiol. 2004 Dec;287(6):C1709-16. doi: 10.1152/ajpcell.00350.2004. Epub 2004 Sep 1. Am J Physiol Cell Physiol. 2004. PMID: 15342342 - Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.
Dietrich A, Mederos y Schnitzler M, Kalwa H, Storch U, Gudermann T. Dietrich A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2005 Apr;371(4):257-65. doi: 10.1007/s00210-005-1052-8. Naunyn Schmiedebergs Arch Pharmacol. 2005. PMID: 15909153 Review.
Cited by
- TRPC4 as a coincident detector of Gi/o and Gq/11 signaling: mechanisms and pathophysiological implications.
Jeon J, Tian JB, Zhu MX. Jeon J, et al. Curr Opin Physiol. 2020 Oct;17:34-41. doi: 10.1016/j.cophys.2020.06.008. Epub 2020 Jul 2. Curr Opin Physiol. 2020. PMID: 32851198 Free PMC article. - Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel.
Smedlund KB, Birnbaumer L, Vazquez G. Smedlund KB, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2201-6. doi: 10.1073/pnas.1505410112. Epub 2015 Apr 13. Proc Natl Acad Sci U S A. 2015. PMID: 25870279 Free PMC article. - Physiological mechanisms of TRPC activation.
Putney JW. Putney JW. Pflugers Arch. 2005 Oct;451(1):29-34. doi: 10.1007/s00424-005-1416-4. Epub 2005 Aug 18. Pflugers Arch. 2005. PMID: 16133266 Review. - Expression of TRPC6 channels in human epithelial breast cancer cells.
Guilbert A, Dhennin-Duthille I, Hiani YE, Haren N, Khorsi H, Sevestre H, Ahidouch A, Ouadid-Ahidouch H. Guilbert A, et al. BMC Cancer. 2008 May 2;8:125. doi: 10.1186/1471-2407-8-125. BMC Cancer. 2008. PMID: 18452628 Free PMC article. - Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons.
Qu L, Li Y, Pan X, Zhang P, LaMotte RH, Ma C. Qu L, et al. J Neurosci. 2012 Jul 11;32(28):9554-62. doi: 10.1523/JNEUROSCI.6355-11.2012. J Neurosci. 2012. PMID: 22787041 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous