Molecular views of recombination proteins and their control - PubMed (original) (raw)

Review

doi: 10.1038/nrm1127.

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• PMID: 12778123
• DOI: 10.1038/nrm1127

Review

Molecular views of recombination proteins and their control

Stephen C West. Nat Rev Mol Cell Biol. 2003 Jun.

Abstract

The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability and cell survival. Homologous recombination provides an efficient and faithful pathway of repair, especially in replicating cells, in which it plays a major role in tumour avoidance. Many of the enzymes that are involved in recombination have been isolated, and the details of this pathway are now being unravelled at the molecular level.

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