Chk1 and Chk2 kinases in checkpoint control and cancer - PubMed (original) (raw)

Review

Chk1 and Chk2 kinases in checkpoint control and cancer

Jiri Bartek et al. Cancer Cell. 2003 May.

Free article

Abstract

Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as candidate tumor suppressors disrupted in sporadic as well as some hereditary malignancies and as potential targets of new anticancer therapies.

PubMed Disclaimer

Similar articles

• The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
  Smith J, Tho LM, Xu N, Gillespie DA. Smith J, et al. Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0. Adv Cancer Res. 2010. PMID: 21034966 Review.
• Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo.
  Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M. Niida H, et al. EMBO J. 2010 Oct 20;29(20):3558-70. doi: 10.1038/emboj.2010.218. Epub 2010 Sep 10. EMBO J. 2010. PMID: 20834228 Free PMC article.
• CHK2 kinase--a busy messenger.
  Bartek J, Falck J, Lukas J. Bartek J, et al. Nat Rev Mol Cell Biol. 2001 Dec;2(12):877-86. doi: 10.1038/35103059. Nat Rev Mol Cell Biol. 2001. PMID: 11733767 Review.
• The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.
  Chen Y, Poon RY. Chen Y, et al. Front Biosci. 2008 May 1;13:5016-29. doi: 10.2741/3060. Front Biosci. 2008. PMID: 18508566 Review.
• Chk1 in the DNA damage response: conserved roles from yeasts to mammals.
  Chen Y, Sanchez Y. Chen Y, et al. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1025-32. doi: 10.1016/j.dnarep.2004.03.003. DNA Repair (Amst). 2004. PMID: 15279789 Review.

Cited by

• Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanoma.
  Barnaba N, LaRocque JR. Barnaba N, et al. Cell Cycle. 2021 Jun;20(11):1041-1051. doi: 10.1080/15384101.2021.1922806. Epub 2021 May 9. Cell Cycle. 2021. PMID: 33966611 Free PMC article. Review.
• Selective inhibition of DNA ligase IV provides additional efficacy to the treatment of anaplastic thyroid cancer.
  Sriramareddy SN, Jamakhani M, Vilanova L, Brossel H, Staumont B, Hamaidia M. Sriramareddy SN, et al. Front Oncol. 2024 Feb 6;14:1323313. doi: 10.3389/fonc.2024.1323313. eCollection 2024. Front Oncol. 2024. PMID: 38380364 Free PMC article.
• Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.
  Magnussen GI, Emilsen E, Giller Fleten K, Engesæter B, Nähse-Kumpf V, Fjær R, Slipicevic A, Flørenes VA. Magnussen GI, et al. BMC Cancer. 2015 Jun 10;15:462. doi: 10.1186/s12885-015-1474-8. BMC Cancer. 2015. PMID: 26054341 Free PMC article.
• Proteomics insights into DNA damage response and translating this knowledge to clinical strategies.
  von Stechow L, Olsen JV. von Stechow L, et al. Proteomics. 2017 Feb;17(3-4):1600018. doi: 10.1002/pmic.201600018. Epub 2016 Dec 12. Proteomics. 2017. PMID: 27682984 Free PMC article. Review.
• Enhancing CHK1 inhibitor lethality in glioblastoma.
  Tang Y, Dai Y, Grant S, Dent P. Tang Y, et al. Cancer Biol Ther. 2012 Apr;13(6):379-88. doi: 10.4161/cbt.19240. Epub 2012 Apr 1. Cancer Biol Ther. 2012. PMID: 22313687 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal