Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death - PubMed (original) (raw)
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death
Sachiko Shinoda et al. Eur J Neurosci. 2003 May.
Abstract
The consequences of activation of tumour necrosis factor receptor 1 (TNFR1) during neuronal injury remain controversial. The apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase, can mediate cell death downstream of TNFR1. Presently, we examined the formation of the TNFR1 signalling cascade and response of ASK1 during seizure-induced neuronal death. Brief (40 min) seizures were induced in rats by intra-amygdala microinjection of kainic acid, which elicited unilateral hippocampal CA3 neuronal death. Seizures caused a rapid decline in the expression of the silencer of death domains protein within injured CA3. Co-immunoprecipitation analysis revealed a commensurate assembly of a TNFR1 scaffold complex containing TNFR-associated death domain protein, receptor interacting protein and TNFR-activating factor 2. In addition, recruitment of TNFR-activating factor 2 was likely promoted by Bcl10-mediated sequestering of cellular inhibitor of apoptosis protein 2. Apoptosis signal-regulating kinase 1 was sequestered in a complex that contained the molecular chaperone 14-3-3beta and protein phosphatase 5. Seizures triggered its dissociation, and the phosphorylation of the ASK1 substrates, mitogen-activated protein kinase kinase 3/6 and 4. Subsequently, protein phosphatase 5 translocated into the nuclei of degenerating CA3 neurons, while ASK1 colocalized with the adaptor proteins Daxx and TNFR-activating factor 2 at the outer membrane of injured CA3 neurons. Neutralizing antibodies to TNFalpha reduced the numbers of DNA damaged cells within the injured hippocampus. These data suggest ASK1 may be involved in the mechanism of seizure-induced neuronal death downstream of a TNFR1 death-signalling complex.
Similar articles
- Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP. Henshall DC, et al. J Neurochem. 2003 Sep;86(5):1260-70. doi: 10.1046/j.1471-4159.2003.01934.x. J Neurochem. 2003. PMID: 12911633 - Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1.
Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC. Cho S, et al. J Biol Chem. 2004 Apr 16;279(16):16050-6. doi: 10.1074/jbc.M305758200. Epub 2004 Feb 4. J Biol Chem. 2004. PMID: 14761963 - Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin.
Liu H, Nishitoh H, Ichijo H, Kyriakis JM. Liu H, et al. Mol Cell Biol. 2000 Mar;20(6):2198-208. doi: 10.1128/MCB.20.6.2198-2208.2000. Mol Cell Biol. 2000. PMID: 10688666 Free PMC article. - Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H. Matsuzawa A, et al. Antioxid Redox Signal. 2002 Jun;4(3):415-25. doi: 10.1089/15230860260196218. Antioxid Redox Signal. 2002. PMID: 12215209 Review. - Death receptor-induced cell killing.
Thorburn A. Thorburn A. Cell Signal. 2004 Feb;16(2):139-44. doi: 10.1016/j.cellsig.2003.08.007. Cell Signal. 2004. PMID: 14636884 Review.
Cited by
- Protein phosphatase 5 protects neurons against amyloid-beta toxicity.
Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S. Sanchez-Ortiz E, et al. J Neurochem. 2009 Oct;111(2):391-402. doi: 10.1111/j.1471-4159.2009.06337.x. Epub 2009 Aug 17. J Neurochem. 2009. PMID: 19686245 Free PMC article. - Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice.
Laing JM, Gober MD, Golembewski EK, Thompson SM, Gyure KA, Yarowsky PJ, Aurelian L. Laing JM, et al. Mol Ther. 2006 May;13(5):870-81. doi: 10.1016/j.ymthe.2005.12.013. Epub 2006 Feb 24. Mol Ther. 2006. PMID: 16500153 Free PMC article. - Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5.
Kutuzov MA, Andreeva AV, Voyno-Yasenetskaya TA. Kutuzov MA, et al. J Biol Chem. 2005 Jul 8;280(27):25388-95. doi: 10.1074/jbc.M413202200. Epub 2005 May 12. J Biol Chem. 2005. PMID: 15890660 Free PMC article. - Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm.
Guo W, Shang DM, Cao JH, Feng K, He YC, Jiang Y, Wang S, Gao YF. Guo W, et al. Biomed Res Int. 2017;2017:6132436. doi: 10.1155/2017/6132436. Epub 2017 Feb 1. Biomed Res Int. 2017. PMID: 28255556 Free PMC article. - Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus.
Engel T, Gómez-Sintes R, Alves M, Jimenez-Mateos EM, Fernández-Nogales M, Sanz-Rodriguez A, Morgan J, Beamer E, Rodríguez-Matellán A, Dunleavy M, Sano T, Avila J, Medina M, Hernandez F, Lucas JJ, Henshall DC. Engel T, et al. Cell Death Dis. 2018 Sep 20;9(10):969. doi: 10.1038/s41419-018-0963-5. Cell Death Dis. 2018. PMID: 30237424 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous