The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair - PubMed (original) (raw)
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The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair
Lea M Starita et al. Curr Opin Cell Biol. 2003 Jun.
Abstract
Interest in BRCA1 stems from its role as a tumour suppressor in breast and ovarian cancer. Intensive research in BRCA1 has revealed little about its specific role in cancer; rather, this protein has been implicated in a multitude of important cellular processes. The diverse biochemical activities of BRCA1 combine to protect the genome from damage. New data reveal that BRCA1 transcriptionally regulates some DNA-repair genes, and, in addition, new roles for BRCA1 have been identified in heterochromatin formation on the X chromosome, double-strand-break repair, and ubiquitination. These diverse activities of BRCA1 may be linked in a single pathway, or BRCA1 might function in multiple nuclear processes.
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