Modifier genes and protective alleles in humans and mice - PubMed (original) (raw)
Review
Modifier genes and protective alleles in humans and mice
Joseph H Nadeau. Curr Opin Genet Dev. 2003 Jun.
Abstract
Interest in modifier genes is growing rapidly because of their ability to modulate the phenotype of individuals with monogenic and multigenic traits and diseases. A neglected class of modifiers is protective alleles that can suppress disease in otherwise susceptible individuals. Together these modifier genes and protective alleles provide important glimpses into the molecular and cellular basis for the functional networks that provide robustness and homeostasis in complex biological systems.
Similar articles
- Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast.
Sirr A, Cromie GA, Jeffery EW, Gilbert TL, Ludlow CL, Scott AC, Dudley AM. Sirr A, et al. Genetics. 2015 Jan;199(1):247-62. doi: 10.1534/genetics.114.170563. Epub 2014 Nov 13. Genetics. 2015. PMID: 25398792 Free PMC article. - Genetic modifiers in human development and malformation syndromes, including chaperone proteins.
Slavotinek A, Biesecker LG. Slavotinek A, et al. Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R45-50. doi: 10.1093/hmg/ddg099. Hum Mol Genet. 2003. PMID: 12668596 Review. - From complex traits to complex alleles.
Phillips PC. Phillips PC. Trends Genet. 1999 Jan;15(1):6-8. doi: 10.1016/s0168-9525(98)01622-9. Trends Genet. 1999. PMID: 10087924 Review. - QTL-based evidence for the role of epistasis in evolution.
Malmberg RL, Mauricio R. Malmberg RL, et al. Genet Res. 2005 Oct;86(2):89-95. doi: 10.1017/S0016672305007780. Genet Res. 2005. PMID: 16356282 Review. - Integrated methods to solve the biological basis of common diseases.
Warden CH, Fisler JS. Warden CH, et al. Methods. 1997 Dec;13(4):347-57. doi: 10.1006/meth.1997.0543. Methods. 1997. PMID: 9480781 Review.
Cited by
- Identification of genetic loci affecting the severity of symptoms of Hirschsprung disease in rats carrying Ednrbsl mutations by quantitative trait locus analysis.
Huang J, Dang R, Torigoe D, Lei C, Lan X, Chen H, Sasaki N, Wang J, Agui T. Huang J, et al. PLoS One. 2015 Mar 19;10(3):e0122068. doi: 10.1371/journal.pone.0122068. eCollection 2015. PLoS One. 2015. PMID: 25790447 Free PMC article. - Investigation on the Effects of Modifying Genes on the Spinal Muscular Atrophy Phenotype.
Zhuri D, Gurkan H, Eker D, Karal Y, Yalcintepe S, Atli E, Demir S, Atli EI. Zhuri D, et al. Glob Med Genet. 2022 Sep 5;9(3):226-236. doi: 10.1055/s-0042-1751302. eCollection 2022 Sep. Glob Med Genet. 2022. PMID: 36071912 Free PMC article. - A Loss-of-Function Mutation in the Integrin Alpha L (Itgal) Gene Contributes to Susceptibility to Salmonella enterica Serovar Typhimurium Infection in Collaborative Cross Strain CC042.
Zhang J, Teh M, Kim J, Eva MM, Cayrol R, Meade R, Nijnik A, Montagutelli X, Malo D, Jaubert J. Zhang J, et al. Infect Immun. 2019 Dec 17;88(1):e00656-19. doi: 10.1128/IAI.00656-19. Print 2019 Dec 17. Infect Immun. 2019. PMID: 31636138 Free PMC article. - A novel susceptibility locus for Hirschsprung's disease maps to 4q31.3-q32.3.
Brooks AS, Leegwater PA, Burzynski GM, Willems PJ, de Graaf B, van Langen I, Heutink P, Oostra BA, Hofstra RM, Bertoli-Avella AM. Brooks AS, et al. J Med Genet. 2006 Jul;43(7):e35. doi: 10.1136/jmg.2005.038125. J Med Genet. 2006. PMID: 16816022 Free PMC article. - Involvement of the modifier gene of a human Mendelian disorder in a negative selection process.
Jéru I, Hayrapetyan H, Duquesnoy P, Cochet E, Serre JL, Feingold J, Grateau G, Sarkisian T, Jeanpierre M, Amselem S. Jéru I, et al. PLoS One. 2009 Oct 30;4(10):e7676. doi: 10.1371/journal.pone.0007676. PLoS One. 2009. PMID: 19888326 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases