Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan - PubMed (original) (raw)

. 2003 Jun 6;300(5625):1584-7.

doi: 10.1126/science.1084677.

Ivo G Boneca, Leticia A M Carneiro, Aude Antignac, Muguette Jéhanno, Jérôme Viala, Karsten Tedin, Muhamed-Kheir Taha, Agnes Labigne, Ulrich Zähringer, Anthony J Coyle, Peter S DiStefano, John Bertin, Philippe J Sansonetti, Dana J Philpott

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Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

Stephen E Girardin et al. Science. 2003.

Abstract

Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largely uncharacterized. Here, we show that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine-N-acetylmuramic acid (GlcNAc-MurNAc) tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-kappaB pathway. Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing.

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