Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast - PubMed (original) (raw)
Review
Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
Malathy P V Shekhar et al. Breast Cancer Res. 2003.
Abstract
Epithelial-mesenchymal interactions play an important role both in normal mammary gland development and during neoplastic transformation. Perturbations in the production, deposition and degradation of the extracellular matrix occurring during neoplastic transformation and progression have been implicated to arise from alterations in the stromal response. These changes in the stroma exhibit a dominant regulatory role, via microenvironmental epigenetic effectors, to contribute to the development of the tumorigenic epithelial phenotype. The role of stromally derived microenvironmental epigenetic effectors in modulating epithelial growth, hormonal response, morphogenesis and epithelial plasticity is discussed.
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References
- Heber D, Ashley J, Bagga D. Stromal–epithelial cell interactions in breast cancer. In: Kritchevsky HD, editor. In Dietary Lipids, Hormones and Tumorigenesis. New York: Plenum Press; 1999. pp. 41–51.
- Ronnov-Jessen L, Petersen OW, Bissell MJ. Cellular changes involved in conversion of normal to malignant breast – importance of the stromal reaction. Physiol Rev. 1996;76:69–125. - PubMed
- Drife JO. Breast development in puberty. In: Angeli A, Bradlow HL, Dogliotti L, editor. In Endocrinology of the Breast: Basic and Clinical Aspects Annals of the New York Academy of Sciences. New York: The New York Academy of Sciences; 1986. pp. 58–65. - PubMed
- Cunha GR, Alarid ET, Turner T, Donjaccour AA, Boutin EL, Foster BA. Normal and abnormal development of the male urogenital tract: role of androgens, mesenchymal-epithelial interactions and growth factors. J Androl. 1992;13:465–475. - PubMed
- Kratochwil K. Tissue combinations and organ culture studies in the development of the embryonic mammary gland. In: Gwatkin RBL, editor. In Developmental Biology: A Comprehensive Synthesis. Vol. 4. New York: Plenum Publishing; 1987. pp. 315–334. - PubMed
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