The genomics and proteomics of biofilm formation - PubMed (original) (raw)

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The genomics and proteomics of biofilm formation

Karin Sauer. Genome Biol. 2003.

Abstract

Bacterial communities that are attached to a surface, so-called biofilms, and their inherent resistance to antimicrobial agents are a cause of many persistent and chronic bacterial infections. Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during biofilm formation, revealing the complexity of this developmental process.

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Figure 1

Figure 1

A model of the stages of bacterial biofilm development. At stage 1, the bacterial cells attach reversibly to the surface. Then, at stage 2, the cells attach irreversibly, a step mediated mainly by exopolymeric substances, and the cells lose their flagella-driven motility. At the next stage (3), the first maturation phase is reached, as indicated by early development of biofilm architecture. The second maturation phase is reached at stage 4 with fully mature biofilms, as indicated by the complex biofilm architecture. At the dispersion stage (5), single motile cells (dark cells on the figure) disperse from the microcolonies. Adapted from [27].

References

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