Truncated Bcl-2, a potential pre-metastatic marker in prostate cancer - PubMed (original) (raw)
Truncated Bcl-2, a potential pre-metastatic marker in prostate cancer
Jen-Ming Huang et al. Biochem Biophys Res Commun. 2003.
Abstract
A novel truncated form of Bcl-2, termed Bcl-2psi, was discovered in invasive prostate cancer cells, using laser capture microdissection, RNA-polymerase cycling reaction, and microarray analysis. The expression of Bcl-2psi increased prior to metastasis in higher-grade prostate cancer. The immunoreactive Bcl-2psi was specifically identified in higher-grade prostate cancer cells. These findings suggest that Bcl-2psi may be a potential pre-metastatic marker for detection, diagnosis, and therapy during the initiation of metastasis in prostate cancer.
Similar articles
- Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma.
Cho-Vega JH, Tsavachidis S, Do KA, Nakagawa J, Medeiros LJ, McDonnell TJ. Cho-Vega JH, et al. Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2615-22. doi: 10.1158/1055-9965.EPI-07-0684. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 18086765 - Androgen regulation of the human pseudoautosomal gene MIC2, a potential marker for prostate cancer.
Shen J, Zhau HE, Hursting SD, Chung LW. Shen J, et al. Mol Carcinog. 1998 Sep;23(1):13-9. Mol Carcinog. 1998. PMID: 9766433 - Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers.
An G, Ng AY, Meka CS, Luo G, Bright SP, Cazares L, Wright GL Jr, Veltri RW. An G, et al. Cancer Res. 2000 Dec 15;60(24):7014-20. Cancer Res. 2000. PMID: 11156405 - The cancer genome anatomy project: online resources to reveal the molecular signatures of cancer.
Strausberg RL, Buetow KH, Greenhut SF, Grouse LH, Schaefer CF. Strausberg RL, et al. Cancer Invest. 2002;20(7-8):1038-50. doi: 10.1081/cnv-120005922. Cancer Invest. 2002. PMID: 12449737 Review. No abstract available.
Cited by
- Doxorubicin selectively induces apoptosis through the inhibition of a novel isoform of Bcl‑2 in acute myeloid leukaemia MOLM‑13 cells with reduced Beclin 1 expression.
Vu M, Kassouf N, Ofili R, Lund T, Bell C, Appiah S. Vu M, et al. Int J Oncol. 2020 Jul;57(1):113-121. doi: 10.3892/ijo.2020.5052. Epub 2020 Apr 23. Int J Oncol. 2020. PMID: 32377726 Free PMC article. - Malignant lesions in the ventral prostate of alloxan-induced diabetic rats.
Ribeiro DL, Marques SF, Alberti S, Spadella CT, Manzato AJ, Taboga SR, Dizeyi N, Abrahamsson PA, Góes RM. Ribeiro DL, et al. Int J Exp Pathol. 2008 Aug;89(4):276-83. doi: 10.1111/j.1365-2613.2008.00591.x. Int J Exp Pathol. 2008. PMID: 18715471 Free PMC article. - Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling.
Nygaard V, Hovig E. Nygaard V, et al. Nucleic Acids Res. 2006 Feb 9;34(3):996-1014. doi: 10.1093/nar/gkj499. Print 2006. Nucleic Acids Res. 2006. PMID: 16473852 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical