A targeting motif involved in sodium channel clustering at the axonal initial segment - PubMed (original) (raw)

. 2003 Jun 27;300(5628):2091-4.

doi: 10.1126/science.1085167.

Affiliations

A targeting motif involved in sodium channel clustering at the axonal initial segment

Juan José Garrido et al. Science. 2003.

Abstract

The sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Nav1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Nav1.2II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, this motif may play a fundamental role in controlling electrical excitability during development and plasticity.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources