Receptor targeting of adeno-associated virus vectors - PubMed (original) (raw)
Review
. 2003 Jul;10(14):1142-51.
doi: 10.1038/sj.gt.3301976.
Affiliations
- PMID: 12833123
- DOI: 10.1038/sj.gt.3301976
Review
Receptor targeting of adeno-associated virus vectors
H Büning et al. Gene Ther. 2003 Jul.
Abstract
Adeno-associated virus (AAV) is a promising vector for human somatic gene therapy. However, its broad host range is a disadvantage for in vivo gene therapy, because it does not allow the selective tissue- or organ-restricted transduction required to enhance the safety and efficiency of the gene transfer. Therefore, increasing efforts are being made to target AAV-2-based vectors to specific receptors. The studies summarized in this review show that it is possible to target AAV-2 to a specific cell. So far, the most promising approach is the genetic modification of the viral capsid. However, the currently available AAV-2 targeting vectors need to be improved with regard to the elimination of the wild-type AAV-2 tropism and the improvement of infectious titers. The creation of highly efficient AAV-2 targeting vectors will also require a better understanding of the transmembrane and intracellular processing of this virus.
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