A "futile cycle" induced by thiazolidinediones in human adipose tissue? - PubMed (original) (raw)

Clinical Trial

. 2003 Jul;9(7):811-2; author reply 812.

doi: 10.1038/nm0703-811.

• PMID: 12835685
• DOI: 10.1038/nm0703-811

Clinical Trial

A "futile cycle" induced by thiazolidinediones in human adipose tissue?

Garry D Tan et al. Nat Med. 2003 Jul.

No abstract available

PubMed Disclaimer

Comment on

• A futile metabolic cycle activated in adipocytes by antidiabetic agents.
  Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA. Guan HP, et al. Nat Med. 2002 Oct;8(10):1122-8. doi: 10.1038/nm780. Epub 2002 Sep 23. Nat Med. 2002. PMID: 12357248

Similar articles

• A futile metabolic cycle activated in adipocytes by antidiabetic agents.
  Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA. Guan HP, et al. Nat Med. 2002 Oct;8(10):1122-8. doi: 10.1038/nm780. Epub 2002 Sep 23. Nat Med. 2002. PMID: 12357248
• Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells.
  Tordjman J, Chauvet G, Quette J, Beale EG, Forest C, Antoine B. Tordjman J, et al. J Biol Chem. 2003 May 23;278(21):18785-90. doi: 10.1074/jbc.M206999200. Epub 2003 Mar 18. J Biol Chem. 2003. PMID: 12644461
• Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.
  Ibrahimi A, Teboul L, Gaillard D, Amri EZ, Ailhaud G, Young P, Cawthorne MA, Grimaldi PA. Ibrahimi A, et al. Mol Pharmacol. 1994 Dec;46(6):1070-6. Mol Pharmacol. 1994. PMID: 7808426
• Role of PPARg2 transcription factor in thiazolidinedione-induced insulin sensitization.
  Saraf N, Sharma PK, Mondal SC, Garg VK, Singh AK. Saraf N, et al. J Pharm Pharmacol. 2012 Feb;64(2):161-71. doi: 10.1111/j.2042-7158.2011.01366.x. Epub 2011 Oct 13. J Pharm Pharmacol. 2012. PMID: 22221092 Review.
• [Insulin sensitizer drugs--review].
  Yamanouchi T. Yamanouchi T. Nihon Rinsho. 2002 Sep;60 Suppl 9:409-15. Nihon Rinsho. 2002. PMID: 12387026 Review. Japanese. No abstract available.

Cited by

• IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification.
  Scaffidi C, Srdic A, Konrad D, Wueest S. Scaffidi C, et al. Adipocyte. 2023 Dec;12(1):2276346. doi: 10.1080/21623945.2023.2276346. Epub 2023 Nov 10. Adipocyte. 2023. PMID: 37948192 Free PMC article.
• Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling.
  Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. Veliova M, et al. EMBO Rep. 2020 Dec 3;21(12):e49634. doi: 10.15252/embr.201949634. Epub 2020 Dec 4. EMBO Rep. 2020. PMID: 33275313 Free PMC article.
• Glycerol is synthesized and secreted by adipocytes to dispose of excess glucose, via glycerogenesis and increased acyl-glycerol turnover.
  Rotondo F, Ho-Palma AC, Remesar X, Fernández-López JA, Romero MDM, Alemany M. Rotondo F, et al. Sci Rep. 2017 Aug 21;7(1):8983. doi: 10.1038/s41598-017-09450-4. Sci Rep. 2017. PMID: 28827624 Free PMC article.
• Stimulation of glycerol kinase in grass carp preadipocytes by EPA.
  Lei C, Tian J, Ji H. Lei C, et al. Fish Physiol Biochem. 2017 Jun;43(3):813-822. doi: 10.1007/s10695-016-0336-x. Epub 2017 Jan 5. Fish Physiol Biochem. 2017. PMID: 28058519
• The cell biology of fat expansion.
  Rutkowski JM, Stern JH, Scherer PE. Rutkowski JM, et al. J Cell Biol. 2015 Mar 2;208(5):501-12. doi: 10.1083/jcb.201409063. J Cell Biol. 2015. PMID: 25733711 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Medical

  • MedlinePlus Health Information