Timeline: Z-DNA: the long road to biological function - PubMed (original) (raw)
Review
doi: 10.1038/nrg1115.
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- PMID: 12838348
- DOI: 10.1038/nrg1115
Review
Timeline: Z-DNA: the long road to biological function
Alexander Rich et al. Nat Rev Genet. 2003 Jul.
Abstract
Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the pathology of poxviruses.
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