About CD4pos CD25pos regulatory cells - PubMed (original) (raw)
Review
About CD4pos CD25pos regulatory cells
C Asseman et al. Autoimmun Rev. 2002 Aug.
Abstract
Autoreactive cells that escape from thymic negative selection are either anergized or counter-regulated in the peripheral lymphoid organs by regulatory T (Treg) cells. Most investigated Treg cells are CD4pos cells expressing the alpha chain of the IL-2 receptor (CD25). Absence of this particular population leads to the development of a wide range of autoimmune disorders, suggesting a critical role for CD4pos CD25pos cells in the maintenance of normal immune homeostasis. Numerous studies have aimed at unraveling the mechanisms of regulation, focusing mainly on naturally occurring Treg cells (generated in naive animals) and regulation of CD4pos autoreactive cells. In contrast, generation following antigenic priming of CD4pos CD25pos Treg cells with non-self (viral) antigen specificity and regulation of virus-activated CD4pos and CD8pos cells remain to be investigated. In this review, we describe the data collected over the past few years of intense focus on CD4pos CD25pos Treg cells and present our approach to investigate the generation of antigen-specific Treg cells during the course of an anti-viral immune response.
Similar articles
- Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.
Coutinho A, Caramalho I, Seixas E, Demengeot J. Coutinho A, et al. Curr Top Microbiol Immunol. 2005;293:43-71. doi: 10.1007/3-540-27702-1_3. Curr Top Microbiol Immunol. 2005. PMID: 15981475 Review. - Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.
Fisson S, Darrasse-Jèze G, Litvinova E, Septier F, Klatzmann D, Liblau R, Salomon BL. Fisson S, et al. J Exp Med. 2003 Sep 1;198(5):737-46. doi: 10.1084/jem.20030686. Epub 2003 Aug 25. J Exp Med. 2003. PMID: 12939344 Free PMC article. - Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process.
Karim M, Kingsley CI, Bushell AR, Sawitzki BS, Wood KJ. Karim M, et al. J Immunol. 2004 Jan 15;172(2):923-8. doi: 10.4049/jimmunol.172.2.923. J Immunol. 2004. PMID: 14707064 - Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals.
Cavani A, Nasorri F, Ottaviani C, Sebastiani S, De Pità O, Girolomoni G. Cavani A, et al. J Immunol. 2003 Dec 1;171(11):5760-8. doi: 10.4049/jimmunol.171.11.5760. J Immunol. 2003. PMID: 14634084 - CD4+CD25+ regulatory T cells: II. Origin, disease models and clinical aspects.
Nielsen J, Holm TL, Claesson MH. Nielsen J, et al. APMIS. 2004 Oct;112(10):642-50. doi: 10.1111/j.1600-0463.2004.apm1121002.x. APMIS. 2004. PMID: 15601315 Review.
Cited by
- Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma.
Li T, Jiao J, Ke H, Ouyang W, Wang L, Pan J, Li X. Li T, et al. Front Immunol. 2023 Jun 29;14:1200201. doi: 10.3389/fimmu.2023.1200201. eCollection 2023. Front Immunol. 2023. PMID: 37457718 Free PMC article. Review. - Effects of rhubarb on the expression of glucocorticoids receptor and regulation of cellular immunity in burn-induced septic rats.
Liu J, Li G, Chen YZ, Zhang LD, Wang T, Wen ZL, Wang L, Chen DC. Liu J, et al. Chin Med J (Engl). 2019 May 20;132(10):1188-1193. doi: 10.1097/CM9.0000000000000201. Chin Med J (Engl). 2019. PMID: 31140990 Free PMC article. - Change in the Treg/Th17 cell imbalance in hepatocellular carcinoma patients and its clinical value.
Lan YT, Fan XP, Fan YC, Zhao J, Wang K. Lan YT, et al. Medicine (Baltimore). 2017 Aug;96(32):e7704. doi: 10.1097/MD.0000000000007704. Medicine (Baltimore). 2017. PMID: 28796055 Free PMC article. - Proinflammatory cytokine interferon-γ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease.
Serena G, Yan S, Camhi S, Patel S, Lima RS, Sapone A, Leonard MM, Mukherjee R, Nath BJ, Lammers KM, Fasano A. Serena G, et al. Clin Exp Immunol. 2017 Mar;187(3):490-506. doi: 10.1111/cei.12911. Epub 2017 Jan 12. Clin Exp Immunol. 2017. PMID: 27936497 Free PMC article. - Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels.
Chang JB, Xue R, Zhou ZX, Feng YH, Dai WW, Qiu J, Yang YF. Chang JB, et al. Exp Ther Med. 2014 Jul;8(1):165-168. doi: 10.3892/etm.2014.1675. Epub 2014 Apr 8. Exp Ther Med. 2014. PMID: 24944616 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous