Selective delta-opioid receptor antagonist N,N(CH3)2-Dmt-Tic-OH does not reduce ethanol intake in alcohol-preferring AA rats - PubMed (original) (raw)
Selective delta-opioid receptor antagonist N,N(CH3)2-Dmt-Tic-OH does not reduce ethanol intake in alcohol-preferring AA rats
Kimmo Ingman et al. Addict Biol. 2003 Jun.
Abstract
We studied the effect of a novel delta-opioid receptor antagonist N,N(CH(3))(2)Dmt-Tic-OH (Me(2)-Dmt-Tic-OH) on voluntary ethanol intake in an alcohol-preferring AA (Alko, Alcohol) rat line using a 4-hour limited access paradigm. Acute injections of Me(2)-Dmt-Tic-OH (10 and 30 mg/kg, i.p.) did not reduce 1-hour or 4-hour ethanol intake. Subtype non-selective opioid receptor antagonist naltrexone [0.1 and 0.3 mg/kg, subcutaneously (s.c.)] significantly reduced 1-hour ethanol drinking but had no effect on 4-hour ethanol consumption. Locomotor stimulation induced by the delta-opioid receptor agonist Tyr-D-Pen-Gly-Phe-D-Pen (DPDPE; 15 microg, intracerebroventricularly) was significantly attenuated by Me(2)-Dmt-Tic-OH (10 and 30 mg/kg, i.p.), which confirmed its efficacy as a delta-opioid receptor antagonist in rat brain. Our results support the idea that delta-opioid receptors do not mediate alcohol reward in AA rats.
Similar articles
- Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Salvadori S, Balboni G, Guerrini R, Tomatis R, Bianchi C, Bryant SD, Cooper PS, Lazarus LH. Salvadori S, et al. J Med Chem. 1997 Sep 12;40(19):3100-8. doi: 10.1021/jm9607663. J Med Chem. 1997. PMID: 9301674 - Supraspinal delta- and mu-opioid receptors mediate gastric mucosal protection in the rat.
Gyires K, Rónai AZ. Gyires K, et al. J Pharmacol Exp Ther. 2001 Jun;297(3):1010-5. J Pharmacol Exp Ther. 2001. PMID: 11356923 - Direct influence of C-terminally substituted amino acids in the Dmt-Tic pharmacophore on delta-opioid receptor selectivity and antagonism.
Balboni G, Salvadori S, Guerrini R, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH. Balboni G, et al. J Med Chem. 2004 Jul 29;47(16):4066-71. doi: 10.1021/jm040033f. J Med Chem. 2004. PMID: 15267245 - The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.
Schiller PW, Weltrowska G, Berezowska I, Nguyen TM, Wilkes BC, Lemieux C, Chung NN. Schiller PW, et al. Biopolymers. 1999;51(6):411-25. doi: 10.1002/(SICI)1097-0282(1999)51:6<411::AID-BIP4>3.0.CO;2-Z. Biopolymers. 1999. PMID: 10797230 Review. - Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics.
Schiller PW, Weltrowska G, Schmidt R, Berezowska I, Nguyen TM, Lemieux C, Chung NN, Carpenter KA, Wilkes BC. Schiller PW, et al. J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):573-88. doi: 10.3109/10799899909036673. J Recept Signal Transduct Res. 1999. PMID: 10071786 Review.
Cited by
- Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.
Bell RL, Sable HJ, Colombo G, Hyytia P, Rodd ZA, Lumeng L. Bell RL, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):119-55. doi: 10.1016/j.pbb.2012.07.007. Epub 2012 Jul 25. Pharmacol Biochem Behav. 2012. PMID: 22841890 Free PMC article. Review. - Ethanol-induced delta-opioid receptor modulation of glutamate synaptic transmission and conditioned place preference in central amygdala.
Bie B, Zhu W, Pan ZZ. Bie B, et al. Neuroscience. 2009 May 5;160(2):348-58. doi: 10.1016/j.neuroscience.2009.02.049. Epub 2009 Mar 1. Neuroscience. 2009. PMID: 19258026 Free PMC article. - A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats.
Nielsen CK, Simms JA, Pierson HB, Li R, Saini SK, Ananthan S, Bartlett SE. Nielsen CK, et al. Biol Psychiatry. 2008 Dec 1;64(11):974-81. doi: 10.1016/j.biopsych.2008.07.018. Epub 2008 Sep 6. Biol Psychiatry. 2008. PMID: 18774553 Free PMC article. - Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption.
Margolis EB, Fields HL, Hjelmstad GO, Mitchell JM. Margolis EB, et al. J Neurosci. 2008 Nov 26;28(48):12672-81. doi: 10.1523/JNEUROSCI.4569-08.2008. J Neurosci. 2008. PMID: 19036960 Free PMC article. - Behavioral, neurobiological, and neurochemical mechanisms of ethanol self-administration: A translational review.
Vena AA, Zandy SL, Cofresí RU, Gonzales RA. Vena AA, et al. Pharmacol Ther. 2020 Aug;212:107573. doi: 10.1016/j.pharmthera.2020.107573. Epub 2020 May 11. Pharmacol Ther. 2020. PMID: 32437827 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical