siRNA-mediated antitumorigenesis for drug target validation and therapeutics - PubMed (original) (raw)
Affiliations
- PMID: 12870431
Review
siRNA-mediated antitumorigenesis for drug target validation and therapeutics
Patrick Y Lu et al. Curr Opin Mol Ther. 2003 Jun.
Abstract
Application of siRNA to knockdown a specific gene requires target mRNA accessibility, effective intracellular delivery of siRNA into target cells and potent siRNA inhibition of target mRNA. Use of siRNA as a tool is advancing in almost every field of biomedical research, but some of the most dynamic and exciting applications of siRNA are in cancer research. This review summarizes the results obtained with siRNA in cancer, in particular functional validation of tumorigenic genes in cell culture and animal tumor models, effective siRNA delivery systems, efficiency of siRNA agents compared with antisense oligonucleotides and efforts for potential therapeutic development. Along with the rapidly growing literature on using siRNA as a functional genomic tool, there is emerging evidence that siRNA may represent a novel therapeutic modality for cancer treatment when optimized local and systemic delivery systems are available.
Similar articles
- Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer.
Jonson AL, Rogers LM, Ramakrishnan S, Downs LS Jr. Jonson AL, et al. Gynecol Oncol. 2008 Nov;111(2):356-64. doi: 10.1016/j.ygyno.2008.06.033. Epub 2008 Aug 27. Gynecol Oncol. 2008. PMID: 18755502 - Short interfering RNA (siRNA): tool or therapeutic?
Cejka D, Losert D, Wacheck V. Cejka D, et al. Clin Sci (Lond). 2006 Jan;110(1):47-58. doi: 10.1042/CS20050162. Clin Sci (Lond). 2006. PMID: 16336204 Review. - Advances in the development of siRNA-based therapeutics for cancer.
Shen Y. Shen Y. IDrugs. 2008 Aug;11(8):572-8. IDrugs. 2008. PMID: 18683092 Review. - Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).
Vandenbroucke RE, De Geest BG, Bonné S, Vinken M, Van Haecke T, Heimberg H, Wagner E, Rogiers V, De Smedt SC, Demeester J, Sanders NN. Vandenbroucke RE, et al. J Gene Med. 2008 Jul;10(7):783-94. doi: 10.1002/jgm.1202. J Gene Med. 2008. PMID: 18470950 - siRNA-mediated type 1 insulin-like growth factor receptor silencing induces chemosensitization of a human liver cancer cell line with mutant P53.
Niu J, Xu Z, Li XN, Han Z. Niu J, et al. Cell Biol Int. 2007 Feb;31(2):156-64. doi: 10.1016/j.cellbi.2006.09.021. Epub 2006 Oct 4. Cell Biol Int. 2007. PMID: 17097318
Cited by
- In vivo application of RNA interference: from functional genomics to therapeutics.
Lu PY, Xie F, Woodle MC. Lu PY, et al. Adv Genet. 2005;54:117-42. doi: 10.1016/S0065-2660(05)54006-9. Adv Genet. 2005. PMID: 16096010 Free PMC article. Review. - Harnessing in vivo siRNA delivery for drug discovery and therapeutic development.
Xie FY, Woodle MC, Lu PY. Xie FY, et al. Drug Discov Today. 2006 Jan;11(1-2):67-73. doi: 10.1016/S1359-6446(05)03668-8. Drug Discov Today. 2006. PMID: 16478693 Free PMC article. Review. - Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics.
Mansoor M, Melendez AJ. Mansoor M, et al. Gene Regul Syst Bio. 2008 Sep 22;2:275-95. doi: 10.4137/grsb.s418. Gene Regul Syst Bio. 2008. PMID: 19787090 Free PMC article. - Challenges and Opportunities Arising from Host-Botrytis cinerea Interactions to Outline Novel and Sustainable Control Strategies: The Key Role of RNA Interference.
Spada M, Pugliesi C, Fambrini M, Pecchia S. Spada M, et al. Int J Mol Sci. 2024 Jun 20;25(12):6798. doi: 10.3390/ijms25126798. Int J Mol Sci. 2024. PMID: 38928507 Free PMC article. Review. - Therapeutic opportunities of small interfering RNA.
Goyal BR, Patel MM, Soni MK, Bhadada SV. Goyal BR, et al. Fundam Clin Pharmacol. 2009 Aug;23(4):367-86. doi: 10.1111/j.1472-8206.2009.00694.x. Fundam Clin Pharmacol. 2009. PMID: 19709318 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical