Practical aspects of in vivo antimalarial drug efficacy testing in the Americas - PubMed (original) (raw)
Affiliations
- PMID: 12875285
Practical aspects of in vivo antimalarial drug efficacy testing in the Americas
Trenton K Ruebush 2nd et al. Am J Trop Med Hyg. 2003 Apr.
Abstract
The World Health Organization (WHO) has developed guidelines for in vivo antimalarial drug efficacy testing for Plasmodium falciparum and Plasmodium vivax in areas with low-to-moderate transmission, such as the Americas. These guidelines are used widely by ministries of health and national malaria control programs to assess the efficacy of their first-line and second-line drugs for the treatment of malaria and to provide the information necessary to update national malaria treatment policies. Following the WHO guidelines, we have conducted in vivo efficacy trials with a variety of drugs and drug combinations against P. falciparum and P. vivax at 13 sites in Peru, Bolivia, and Ecuador. Based on these experiences, we have identified several modifications that we believe should be made in the WHO recommendations to make them more suitable to the relatively low levels of P. falciparum transmission in the Americas and to the logistic challenges of carrying out such studies in sparsely populated areas, such as the Amazon Basin. These include changes in inclusion and exclusion criteria, in enrollment and follow-up procedures, and in the measurement of study outcomes.
Similar articles
- Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea.
Marfurt J, Müeller I, Sie A, Maku P, Goroti M, Reeder JC, Beck HP, Genton B. Marfurt J, et al. Am J Trop Med Hyg. 2007 Nov;77(5):947-54. Am J Trop Med Hyg. 2007. PMID: 17984359 Clinical Trial. - Modifying national malaria treatment policies in Peru.
Ruebush TK 2nd, Neyra D, Cabezas C. Ruebush TK 2nd, et al. J Public Health Policy. 2004;25(3-4):328-45. doi: 10.1057/palgrave.jphp.3190032. J Public Health Policy. 2004. PMID: 15683069 - Sulfadoxine-pyrimethamine plus artesunate compared with chloroquine for the treatment of vivax malaria in areas co-endemic for Plasmodium falciparum and P. vivax: a randomised non-inferiority trial in eastern Afghanistan.
Kolaczinski K, Durrani N, Rahim S, Rowland M. Kolaczinski K, et al. Trans R Soc Trop Med Hyg. 2007 Nov;101(11):1081-7. doi: 10.1016/j.trstmh.2007.06.015. Epub 2007 Aug 17. Trans R Soc Trop Med Hyg. 2007. PMID: 17707447 Clinical Trial. - Responding to the challenge of antimalarial drug resistance by routine monitoring to update national malaria treatment policies.
Vestergaard LS, Ringwald P. Vestergaard LS, et al. Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):153-9. Am J Trop Med Hyg. 2007. PMID: 18165488 Review. - The co-existence of Plasmodium: sidelights from falciparum and vivax malaria in Thailand.
Snounou G, White NJ. Snounou G, et al. Trends Parasitol. 2004 Jul;20(7):333-9. doi: 10.1016/j.pt.2004.05.004. Trends Parasitol. 2004. PMID: 15193565 Review. No abstract available.
Cited by
- Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria.
Bacon DJ, McCollum AM, Griffing SM, Salas C, Soberon V, Santolalla M, Haley R, Tsukayama P, Lucas C, Escalante AA, Udhayakumar V. Bacon DJ, et al. Antimicrob Agents Chemother. 2009 May;53(5):2042-51. doi: 10.1128/AAC.01677-08. Epub 2009 Mar 2. Antimicrob Agents Chemother. 2009. PMID: 19258269 Free PMC article. - Therapeutic efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum in Haiti after many decades of its use.
Okech BA, Existe A, Romain JR, Memnon G, Victor YS, de Rochars MB, Fukuda M. Okech BA, et al. Am J Trop Med Hyg. 2015 Mar;92(3):541-5. doi: 10.4269/ajtmh.14-0302. Epub 2015 Jan 19. Am J Trop Med Hyg. 2015. PMID: 25601993 Free PMC article. - Effect of artesunate-mefloquine fixed-dose combination in malaria transmission in Amazon basin communities.
Santelli AC, Ribeiro I, Daher A, Boulos M, Marchesini PB, dos Santos RL, Lucena MB, Magalhães I, Leon AP, Junger W, Ladislau JL. Santelli AC, et al. Malar J. 2012 Aug 20;11:286. doi: 10.1186/1475-2875-11-286. Malar J. 2012. PMID: 22905900 Free PMC article. - A database of antimalarial drug resistance.
Sibley CH, Ringwald P. Sibley CH, et al. Malar J. 2006 Jun 15;5:48. doi: 10.1186/1475-2875-5-48. Malar J. 2006. PMID: 16774688 Free PMC article. - Effectiveness of combined chloroquine and primaquine treatment in 14 days versus intermittent single dose regimen, in an open, non-randomized, clinical trial, to eliminate Plasmodium vivax in southern Mexico.
Gonzalez-Ceron L, Rodriguez MH, Sandoval MA, Santillan F, Galindo-Virgen S, Betanzos AF, Rosales AF, Palomeque OL. Gonzalez-Ceron L, et al. Malar J. 2015 Oct 30;14:426. doi: 10.1186/s12936-015-0938-2. Malar J. 2015. PMID: 26518132 Free PMC article. Clinical Trial.