Three or more routes for leukocyte migration into the central nervous system - PubMed (original) (raw)
Review
doi: 10.1038/nri1130.
Affiliations
- PMID: 12876559
- DOI: 10.1038/nri1130
Review
Three or more routes for leukocyte migration into the central nervous system
Richard M Ransohoff et al. Nat Rev Immunol. 2003 Jul.
Abstract
Leukocyte migration into and through tissues is fundamental to normal physiology, immunopathology and host defence. Leukocyte entry into the central nervous system (CNS) is restricted, in part, because of the blood-brain barrier (BBB). During the past decade, crucial components that are involved in the process of leukocyte migration have been identified and progress has been made in understanding the mechanisms of neuroinflammatory reactions. In this review, present knowledge of the trafficking determinants that guide the migration of leukocytes is superimposed onto the vascular and compartmental anatomy of the CNS. We discuss three distinct routes for leukocytes to enter the CNS and consider how different populations of leukocytes use trafficking signals to gain entry.
Similar articles
- Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details.
Rebenko-Moll NM, Liu L, Cardona A, Ransohoff RM. Rebenko-Moll NM, et al. Curr Opin Immunol. 2006 Dec;18(6):683-9. doi: 10.1016/j.coi.2006.09.005. Epub 2006 Sep 28. Curr Opin Immunol. 2006. PMID: 17010588 Review. - Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system.
Cayrol R, Wosik K, Berard JL, Dodelet-Devillers A, Ifergan I, Kebir H, Haqqani AS, Kreymborg K, Krug S, Moumdjian R, Bouthillier A, Becher B, Arbour N, David S, Stanimirovic D, Prat A. Cayrol R, et al. Nat Immunol. 2008 Feb;9(2):137-45. doi: 10.1038/ni1551. Epub 2007 Dec 23. Nat Immunol. 2008. PMID: 18157132 - The blood-brain-barrier in multiple sclerosis: functional roles and therapeutic targeting.
Correale J, Villa A. Correale J, et al. Autoimmunity. 2007 Mar;40(2):148-60. doi: 10.1080/08916930601183522. Autoimmunity. 2007. PMID: 17453713 Review. - T-cell trafficking competence is required for CNS invasion.
Lees JR, Archambault AS, Russell JH. Lees JR, et al. J Neuroimmunol. 2006 Aug;177(1-2):1-10. doi: 10.1016/j.jneuroim.2006.05.024. Epub 2006 Jul 5. J Neuroimmunol. 2006. PMID: 16822552
Cited by
- Immune responses to central nervous system directed adeno-associated virus gene therapy: Does direct CNS delivery make a difference?
Harkins AL, Ambegaokar PP, Keeler AM. Harkins AL, et al. Neurotherapeutics. 2024 Jul;21(4):e00435. doi: 10.1016/j.neurot.2024.e00435. Epub 2024 Aug 23. Neurotherapeutics. 2024. PMID: 39180957 Free PMC article. Review. - Brain Targeting Nanomedicines: Pitfalls and Promise.
Kakinen A, Jiang Y, Davis TP, Teesalu T, Saarma M. Kakinen A, et al. Int J Nanomedicine. 2024 May 27;19:4857-4875. doi: 10.2147/IJN.S454553. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38828195 Free PMC article. Review. - Chronic SIV-Induced neuroinflammation disrupts CCR7+ CD4+ T cell immunosurveillance in the rhesus macaque brain.
Elizaldi SR, Hawes CE, Verma A, Shaan Lakshmanappa Y, Dinasarapu AR, Schlegel BT, Rajasundaram D, Li J, Durbin-Johnson BP, Ma ZM, Pal PB, Beckman D, Ott S, Raeman R, Lifson J, Morrison JH, Iyer SS. Elizaldi SR, et al. J Clin Invest. 2024 Mar 12;134(9):e175332. doi: 10.1172/JCI175332. J Clin Invest. 2024. PMID: 38470479 Free PMC article. - Splenectomy does not affect the development of pneumonia following severe traumatic brain injury.
Uhlich R, Pierce V, Kerby J, Bosarge P, Hu P. Uhlich R, et al. Brain Behav Immun Health. 2019 Nov 14;1:100007. doi: 10.1016/j.bbih.2019.100007. eCollection 2020 Jan. Brain Behav Immun Health. 2019. PMID: 38377417 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous