Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism - PubMed (original) (raw)
. 2003 Aug 15;121B(1):35-8.
doi: 10.1002/ajmg.b.20053.
Affiliations
- PMID: 12898572
- DOI: 10.1002/ajmg.b.20053
Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism
Alessandro Serretti et al. Am J Med Genet B Neuropsychiatr Genet. 2003.
Abstract
We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P = 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP.
Copyright 2003 Wiley-Liss, Inc.
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