Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation - PubMed (original) (raw)
Metabolic imaging of human cognition: an fMRI/1H-MRS study of brain lactate response to silent word generation
Anna S Urrila et al. J Cereb Blood Flow Metab. 2003 Aug.
Abstract
Proton magnetic resonance spectroscopy (1H-MRS) allows in vivo assessment of the metabolism related to human brain functions. Visual, auditory, tactile, and motor stimuli induce a temporary increase in the brain lactate level, which may act as a rapid source of energy for the activated neurons. The authors studied the metabolism of the frontal lobes during cognitive stimulation and measured local lactate levels with standard 1H-MRS, after localizing the activated area by functional MRI. Lactate levels were monitored while the subjects either silently listed numbers (baseline) or performed a silent word-generation task (stimulus-activation). The cognitive stimulus-activation produced a 50% increase in the brain lactate level in the left inferior frontal gyrus. The results show that metabolic imaging of neuronal activity related to cognition is possible using 1H-MRS.
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