A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer - PubMed (original) (raw)
A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer
Justin Lamb et al. Cell. 2003.
Free article
Abstract
Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
Comment in
- Striking it rich by data mining.
Rosen JM. Rosen JM. Cell. 2003 Aug 8;114(3):271-2. doi: 10.1016/s0092-8674(03)00601-9. Cell. 2003. PMID: 12914689 No abstract available.
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